Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 177-205). Also available in print.

Thesis (Ph. D.)--Illinois State University, 1986. / Title from title page screen, viewed July 20, 2005. Dissertation Committee: H. Tak Cheung (chair), Arlan Richardson, Herman Brockman, David Borst, Lynn Lucher. Includes bibliographical references (leaves 115-124) and abstract. Also available in print.

Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 127-146).

Thesis (Ph. D.)--Illinois State University, 1991. / Title from title page screen, viewed December 8, 2005. Dissertation Committee: H. Tak Cheung (chair), Herman E. Brockman, Lynne A. Lucher, Anthony J. Otsuka, Alan J. Katz. Includes bibliographical references (leaves 99-110) and abstract. Also available in print.

Thesis--University of Wisconsin--Madison. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1984. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 125-148).

No description available.

Thesis (MSc. (Pharmacology, Faculty of Medicine))--Universiteit van Pretoria, 2000. / Summary in Afrikaans.

The blood cells of the solitary ascidian, Ciona intestinalis, were examined for lymphocyte-like functions with a view to clarifying the phylogenetic origin of lymphocytes in invertebrates. It was found that cells, present in the circulating blood, mediate the haemolysis of sheep red blood cells, and that a different cell type mediates cytotoxic activity against a range of mammalian tumour cell lines in vitro. The blood cells, cytotoxic to mammalian cell lines, were enriched by continuous density gradient centrifugation, and their activity was ameliorated by heat-treatment. Parameters of cytotoxic activity against the target cell line, WEHI, a mouse myelomonocytic leukemic cell (strain 3B), were ascertained by fluorochromasia and the phenomenon was found to be rapid, temperature dependent and sensitive to osmotic conditions. Cytotoxicity was also found to be dependent upon the presence of magnesium and calcium ions, effector to target cell binding, and active metabolic, cytoskeletal and secretory processes in the effector cells. The cytotoxic cells were non-adherent to glass or nylon wool and transmission electron microscope studies of the target-binding cells showed that they were undifferentiated, with a high nucleus to cytoplasm ratio, containing a few large mitochondria, some profiles of rough endoplasmic reticulum and many free ribosomes. In addition, TEM studies revealed close inter-digitation of the effector and target cell membranes and evidence of secretory activity within the effector cell, in the area of target cell binding. The effector cell population was cultured in vitro and proliferation in response to concanavalin A, phytohaemagglutinin-B, lipopolysaccharide, or allogeneic leucocytes, measured by the uptake of tritiated thymidine, showed that these cells respond to both T and B cell mitogens and exhibit a mixed leucocyte reaction. In addition, the culture of pharyngeal explants and the measurement of cytotoxic activity by cells migrating from the explants indicates that the cytotoxic cells originate in a thymus-like haemopoietic tissue. Therefore, the undifferentiated blood cells of C. intestinalis, possess functional and morphological properties consistent with phylogenetic precursors of vertebrate lymphocytes.