M.S. / Bio-organic Chemistry / Single doses of tetrachlorobiphenyls, shown to be free of any chlorinated dibenzodioxins or dibenzofurans to a level of 1 ppm, were given to rhesus monkeys (Macaca mulatta) and the hepatic microsomal enzyme response measured periodically for 32 days. Liver biopsies, obtained by a closed needle technique, provided the tissue samples. Aryl hydrocarbon hydroxylase (measured as benzo[a]pyrene hydroxylase), aminopyrine - N - demethylase and cytochrome P-450 were measured on each sample. Animals treated with 25 mg/kg body weight of 2,5,2' ,5'- tetrachlorobiphenyl showed a marked increase in the demethylase activity, which peaked at 1 to 2 days after treatment, and had no effect on the x hydroxylase activity or the position of the absorption maximum of the CO difference spectrum of cytochrome P-450. This is phenobarbital like inductive behavior. The animals treated with 1 mg/kg body weight of 3, 4, 3’, 4’-tetrachlorobiphenyl showed a 3-methylcholanthrene type inductive profile. The hydroxylase activity was significantly increased and peaked at 2 days after treatment. The demethylase activity was not changed. The position of the cytochrome P-450 difference spectrum absorption maximum was shifted to 448 nm. The control animals received just the acetone / corn oil vehicle and showed no changes in any of the biochemical activities measured in the course of this experiment. This data supports the structure activity relationships, established in rats, for chlorobiphenyls as inducers of hepatic microsomal enzyme activity in rhesus monkeys.

Over the past few decades, researchers have firmly established that a wide range of nonhuman animals exhibit some form of numerical competence. The focus of this research was to define further the extent of numerical ability in rhesus monkeys, and specifically to determine whether the animals possess a symbolic understanding of Arabic numerals. This required examining the stimulus attributes (e.g., number vs. hedonic value) represented by the numerals, as well as the precision (e.g., absolute vs. relative) and generality of those representations. In chapters 2 and 3, monkeys were required to compare and order numerals and were rewarded with either proportional or probabilistic rewards. The results indicated that monkeys were relying on the ordinal or absolute numerical values associated with each numeral and not hedonic value or learned 2-choice discriminations. The studies in chapters 4 and 5 indicated that monkeys can use numerals to symbolize an approximate number of sequential motor responses. The study in Chapter 6 tested the generality of the monkeys’ symbolic number concept using transfer tests. The results indicated that some monkeys are able to abstract number across presentation mode, but this ability is only exhibited under limited conditions. Collectively, these studies provide evidence that rhesus monkeys view Arabic numerals as more than sign-stimuli associated with specific response-reward histories, but that numerals do not have the same precise symbolic meaning as they do for humans.

Thesis (M.S.)--University of Michigan, 1992.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1958. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 92-94).

Thesis (Ph. D.)--University of Wisconsin, 1958. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.A.)--University of Wisconsin--Madison, 1969. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 138-144).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1963. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 149-156).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 68-76).

Thesis (Ph. D.)--Cornell University, May, 2008. / Vita. Includes bibliographical references (leaves 147-159)

Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 189-196).