Thesis (M.Sc.) -- Dept. of Microbiology, University of Adelaide, 1973.

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Following reports by Shapira et al. that α₂Macro-globulin (α₂M) is abnormal in cystic fibrosis (CF), the author set out to examine the properties of α₂M isolated from the plasma of children with CF and from the plasma of age/sex matched controls. To do so, a technique capable of isolating pure, physiologically "active" α₂M from small plasma samples had to be developed. By a two-step chromatographic technique, involving Cibacron Blue Sepharose chromatography and immuno-adsorption, the author was able to isolate "active" CF and control α₂M of at least 98 percent purity from 5 ml of plasma, regardless of plasma haptoglobin type. Having accomplished this, comparative studies of CF and control α₂M were undertaken. Four parameters were investigated: (1) the molar protease binding of α₂M (2) the interaction of α₂M -bovine cationic trypsin (BCT) complexes with the low molecular weight substrate BAEE, (3) the stability of formed α₂M-BCT complexes, and (4) the subunit structure of α₂M. Contrary to the reports of Shapira and his colleagues, this author found no differences between the subunit structure of CF and control α₂M nor between the abilities of CF and control α₂M to interact with BCT. Based upon these findings, the author believes that no firm evidence exists to implicate an α₂M defect in the pathogenesis of cystic fibrosis. / Medicine, Faculty of / Pathology and Laboratory Medicine, Department of / Graduate

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Thesis (Ph. D.)--University of Virginia, 1997. / Spine title: [alpha]₂-M & LRP in atherosclerosis. Includes bibliographical references (180-195). Also available online through Digital Dissertations.

Thesis (Ph. D.)--Duke University, 2007. / Includes bibliographical references.

Thesis (Ph. D.)--Institute of Paper Chemistry, 1969. / Includes bibliographical references (p. 63-65).

The growing demand for simulated fish products coupled with the declining stocks of traditional fish species for making these products, have increased efforts aimed at developing novel procedures to put non-traditional fish species like bluefish (Pomatomus saltatrix) and tilapia (Tilapia nilotica) to better economic use. Two procedures which fulfill both objectives are (i) application of high hydrostatic pressure, and (ii) utilization of protease inhibitor to control fresh fish spoilage due to microbial activity and/or autolysis by endogenous enzymes. High hydrostatic pressure has been used to formulate gels with superior functional properties, while $ alpha sb2$-macroglobulin, a broad spectrum protease inhibitor, has been added to control proteolysis in fish gels during processing and storage. / In this study, high pressure was applied at levels of 300 to 3,742 atm for 30 min to formulate gels from bluefish meat paste, and the properties of the resulting gels were compared with those of heat-induced gels formulated at 90$ sp circ$C for 20 min or 60$ sp circ$C for 60 min. / The effects of $ alpha sb2$-macroglobulin and cooking temperatures on the properties of tilapia gels were also studied. (Abstract shortened by UMI.)

Thesis (M.Sc.)--University of Wollongong, 2008. / Typescript. Includes bibliographical references (p. 107-120)

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