Thesis (Ph. D.)--Michigan State University. Biochemistry and Molecular Biology, 2008. / Title from PDF t.p. (Proquest, viewed on Aug. 18, 2009) Includes bibliographical references. Also issued in print.

Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references. Also available online.

Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references. Also available in print.

Thesis (M.Sc.)--York University, 2005. Graduate Programme in Chemistry. / Typescript. Includes bibliographical references. Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11936

Thesis (M.S.)--University of North Carolina at Greensboro, 2007. / Title from PDF title page screen. Advisor: Gregory M. Raner; submitted to the Dept. of Chemistry. Includes bibliographical references (p. 78-80).

Dissertation (Ph.D.).--University of Texas Graduate School of Biomedical Sciences at San Antonio, 2005. / Vita. Includes bibliographical references.

This thesis presents the results of the first application of a novel solid state nuclear magnetic resonance technique (K. P. Pauls et. al., Eur. Biophys. J. 11:1) to a naturally occuring membrane polypeptide. Deuterium NMR was used to study the structure and dynamics of hydrogen-exchanged gramicidin A', an ion channel, in model membranes. The technique exploits recently developed procedures for solvent-signal suppression (P. T. Callaghan et. al., J. Magn. Reson. 56:101), and "depakeing" powder spectra (E. Sternin, M.Sc. Thesis,U.B.C.). The spectra of gramicidin A' in crystalline form, and in the gel phase of the lipid bilayer are similar and indicate little molecular motion on the NMR timescale. In the liquid crystalline phase, however, the spectra suggest rapid uniaxial rotation of the gramicidin about the bilayer director. The frequencies of the liquid crystalline phase spectra were found to be independent of bilayer thickness, temperature, and the presence of sodium chloride, in the ranges investigated. The results are discussed in the context of the conduction properties of the gramicidin ion channel, other spectroscopic studies, and thecretical models of the structure and action of gramicidin. / Science, Faculty of / Physics and Astronomy, Department of / Graduate

No description available.

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy