Health and reducing disparities in health between and within countries are among the principal global sustainable development objectives for the period 2016-2030. The incidence of Occupational Diseases (OD) is characterized by very distinct differentiation, both regional and sectoral, and has considerable dynamics in time and place. Given that Czechia is at the top among all EU member states in terms of employment in the automotive industry and production of new vehicles, new research on OD in the automotive industry acquires importance. The Ph.D. Thesis is conceived as an ecological correlation study focusing on the study of the determinants of OD in automotive industry. Its own core work is to analyze 32,646 cases of OD (in the past 20 years) and a set of data from a survey of 247 companies of the automotive industry (employing nearly 110,000 employees, i.e. 78 % of the economically active population working in this sector). In the present work are used available data from routine statistics, data from registers and basic sanitation data from a questionnaire survey. The study innovatively links research of Global production networks and medical-geographical approach. At the end of the Ph.D. Thesis, specific outcomes for praxis and discusses possible topics for further research in this area are...