A Kaizen event (KE) may be defined as a structured improvement project that uses a cross-functional team and specific improvement goals to improve a targeted work area or process in an accelerated time frame. KEs, also known as Rapid Improvement Events (RIEs), have been utilized within hospitals to achieve beneficial operations, stakeholder (i.e., social), financial, and clinical outcomes. Due to their potential to achieve positive results in a rapid timeframe, understanding the determinants of KE success within a hospital environment is a valuable research undertaking. To date there has been limited rigorous empirical quantitative research focused on identifying success factors (SFs) influencing socio-technical outcomes of hospital-based KEs. Hence, this empirical research study seeks to determine the critical success factors (CSFs) for KEs in hospitals. For the first phase of this research work, a comprehensive systematic literature review (SLR) was conducted to identify the success factors (SFs) for KEs in hospitals as reported in the literature. This SLR resulted in the identification of 54 unique success factors mapping to four broad success factor categories, KE Task Design, KE Team Design, Organization, and KE Process. Thereafter, the second phase, which involved the variable reduction process, was performed to determine the strength of effect, or importance, of the SFs in order to determine a feasible number of SFs to include in further empirical work. Two robust methods were applied; a Meta-synthesis Evaluation and an Expert Survey, to query the SFs and to determine high priority factors for the empirical study. As a result, a total of 30 factors were finalized for empirical study. Next, the last phase, the empirical study to investigate and determine the CSFs for KEs in hospitals, was executed using a retrospective field study survey research design. Specifically, a survey questionnaire was designed to elicit feedback on perceptual measures from targeted hospital KE facilitators/leaders on the criticality of SFs on socio-technical outcomes for KEs in hospitals. Sixty usable responses were obtained, which were subjected to Exploratory Factor Analysis (EFA) and Partial Least Squares-Structural Equation Modeling (PLS-SEM), which were used to identify latent factor constructs and to determine the significance of the SFs, respectively. The results of this study identified seven significant direct relationships. Kaizen Event Design Characteristics (KEDC) and Target Area Buy-in (TABI) were found to have significant direct effects with both dependent variables, Performance Impact (PI) and Growth in Kaizen Capabilities (KCG). In addition, KEDC also had a significant direct relationship with Performance Culture (PC) and Team Dynamics (TD), respectively. Also, PC has a significant direct relationship with TD. Furthermore, Logistic Regression was utilized to test the SFs impact on the one objective technical outcome measure in the study, Goal Attainment (GOALATT). This analysis revealed one significant negative relationship occurring between TD and GOALATT. Overall, the study's findings provide evidence-based results for informing hospital managers, leaders, and continuous improvement practitioners on the key factors or value-added practices that can be adopted in their hospital KE initiatives to achieve beneficial socio-technical outcomes, as well as overall hospital KE success. Furthermore, this research can enable academia/researchers to strategize more confirmatory analysis approaches for theory validation and generalizability. / Doctor of Philosophy / The focus of this research study is to identify the most significant factors for Kaizen events (KEs) in hospitals, referred herein as critical success factors (CSFs). A KE may be defined as a structured improvement project that uses a cross-functional team and specific improvement goals to improve a targeted work area or process in an accelerated time frame. The aim of the study is to ultimately improve KE practice in hospitals through increased understanding of CSFs that can be planned or designed into KE processes to increase the likelihood of successful event outcomes. Various research formulation, development, and testing techniques are applied to frame the research study according to the aims and objectives and to achieve targeted research outcomes. The overall research design encompasses a retrospective study approach, performing a large-scale field study using a survey questionnaire to empirically identify the CSFs for KEs in hospitals. To help frame the research, a systematic literature review (SLR) along with bibliometric analyses were conducted. To help refine and select the success factors for empirical study, a meta-synthesis evaluation and an expert survey study were conducted. Exploratory factor analysis (EFA) and partial least squares-structural equation modeling (PLS-SEM) along with mediation analyses (MA) were performed to identify key factors, determine the significance of those factors, and to understand the influential relationships of those factors to hospital KE success. Results from this study aim to inform healthcare managers, healthcare improvement practitioners, researchers, and other relevant stakeholders about the critical components needed to achieve hospital KE success. The dissertation is documented according to a "manuscript style," using a journal/conference paper format to organize and report on the key findings and results obtained from the investigation. The Introduction chapter is provided to introduce the research study topic, study significance, indicate the overall research aims and objectives, present the overall research approach and design methodology, and to enumerate the main publication outputs and outcomes from this dissertation work. The Conclusions chapter summarizes the overall research outcomes, key study findings, study limitations, and provides areas for future research.