Thesis (Ph. D.)--University of Wisconsin--Madison, 1956. / Typescript. Vita. Includes Effect of fluoride and dinitrophenol on acetate activation in kidney and liver homogenates, by A.C. Aisenberg and V.R. Potter, reprinted from the Journal of biological chemistry, v. 215 (1955) no. 2, p. 737-749. Includes bibliographical references (leaves 80-83).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1981. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 203-217).

Thesis (M.S.)--University of Wisconsin--Madison, 1961. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 70-73).

Thesis (Ph. M.)--University of Wisconsin--Madison, 1937. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 33-36).

Thesis (M.D.)--University of Hong Kong, 1959. / Includes bibliography. Also available in print.

Several insect species can use the amino acid proline as a major energy substrate, a unique characteristic of these animals. Although initially thought to be limited to blood feeding dipterans, studies revealed this capability may be more widespread. Recent work showed that the bumblebee Bombus impatiens can oxidize proline at a high rate, as measured using isolated flight muscle. However, its role as a metabolic fuel to power flight is unclear. To elucidate the extent to which proline is oxidized to power flight and how its contribution changes during flight, metabolites of central carbon and proline metabolism were profiled at key time points in hemolymph and flight muscle tissue. Analysis using UPLC-MS-QTOF has revealed trends in fuel use and changes in pathway metabolites. Of 29 targeted metabolites, 18 were detected in flight muscle tissue. Two flight experiments were conducted and concentrations of metabolites at the end of prolonged flight are similar to those at rest, or have decreased significantly. In total, 14 of 19 metabolites significantly changed in concentration. The results correspond to a model of fuel use during flight, which states that proline is oxidized at the onset of flight, then carbohydrates take over as the main fuel, accompanied by a decrease in glycogen. By 8 minutes of flight, metabolite concentrations stabilize and flight performance does not change. Patterns in metabolite fluctuations suggest proline is used to supplement the Krebs cycle, and carbohydrates are the main fuel, maintained by glycogen stores. This indicates homeostatic regulation of intermediates and replenishment of fuels, or depletion of fuels due to their recruitment for ATP generation. This targeted metabolomics approach will clarify the role of proline and carbohydrate metabolism and pathway regulation during flight in B. impatiens.

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / This study investigates whether an 8-week lifestyle-based, smartphone-delivered intervention targeting reduction in sedentary behavior (i.e., sitting) significantly reduces objectively measured time spent sitting and improves fasting glucose and insulin. The incidence of type II diabetes has continued to increase in the United States and increases in sedentary behavior along with reductions in physical activity throughout the day have contributed to the increase of disease. There were 31 participants in the study and they started with a 3-week run-in period where a basic self- monitoring component was installed on their smartphone. After this run-in period, participants were randomly assigned to one of the eight experimental conditions. All participants received a basic self-monitoring with feedback component where they self-reported sleep, sedentary, and more active behaviors. Sitting time was measured with the activPAL3c, which is a device that they wore 24/7. Study visits occurred at week 0 (immediately after the 3-week run-in period), week 4, and week 8. Fasting glucose and insulin were measured at each of these visits. Participants logged approximately 60% of their sleep, sedentary, and exercise behaviors, which took 3– 4 min/day to complete. The impact of the intervention was not significant, such that decreases in sedentary time in those assigned to the sedentary component did not significantly differ from those not assigned to the sedentary component at 8 weeks (beta (SE) = -1.19 (.32), p>0.05); however, the effect size was moderate (Cohen’s d = 0.29). There was no significant impact on fasting glucose or insulin.

No description available.

Typescript, etc.

Typescript, etc.