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Sex Differences in Initiation and Expression of Methylplhenidate Sensitization in Adolescent Rats: Analysis of Accumbal and Striatal BDNFRoeding, Ross L., Perna, Marla K., Brown, Russell W. 04 May 2012 (has links)
This study analyzed locomotor sensitization to methylphenidate (MPH, Trade name: Ritalin) in adolescent male and female rats. Females, but not males, demonstrated locomotor sensitization. Interestingly, females given MPH demonstrated a significant decrease of brain derived neurotrophic factor (BDNF) in the striatum, whereas males demonstrated an increase in this same brain area.
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