NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

Xiao, Mei, Yang, Hongsong, Klein, Suzane M., Muenyi, Christian M., Stone, William L., Jiang, Yu L. 01 October 2008 (has links)
A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give t-butyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.
anticancer drug
design
LNCaP cancer cell lines
mild conditions
NCX 4040
prostate cancer
synthesis
Pediatrics

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