Spelling suggestions: "subject:"mirror neuronal system""
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The Mirror Neuron System and Its Role in Autism Spectrum DisorderWestlund, Kristina January 2009 (has links)
The discovery of mirror neurons and the mirror neuron system is one of the most interesting breakthroughs in the field of neuroscience in recent years. The topic stretches over a wide spectrum of research fields but one of the more prominent areas is concerned with the role of mirror neurons in autism spectrum disorder. It is hypothesized that an impaired mirror neuron system may be one of the main causes underlying the deficits seen in autistic individuals. Parallel to the broken mirror theory of autism there are critical voices claiming there is not enough empirical evidence to support such a theory. Research carried out in the area seems to offer support for both contradictory approaches making it hard to conclude the definite role of mirror neurons in this developmental disorder. Future research may offer conclusive answers concerning the role of the mirror neuron system in autism spectrum disorder as well as other important questions regarding the functional properties of the brain areas under question.
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The Mirror Neuron System and Its Role in Autism Spectrum DisorderWestlund, Kristina January 2009 (has links)
<p>The discovery of mirror neurons and the mirror neuron system is one of the most interesting breakthroughs in the field of neuroscience in recent years. The topic stretches over a wide spectrum of research fields but one of the more prominent areas is concerned with the role of mirror neurons in autism spectrum disorder. It is hypothesized that an impaired mirror neuron system may be one of the main causes underlying the deficits seen in autistic individuals. Parallel to the broken mirror theory of autism there are critical voices claiming there is not enough empirical evidence to support such a theory. Research carried out in the area seems to offer support for both contradictory approaches making it hard to conclude the definite role of mirror neurons in this developmental disorder. Future research may offer conclusive answers concerning the role of the mirror neuron system in autism spectrum disorder as well as other important questions regarding the functional properties of the brain areas under question.</p>
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Development of a Robotic Device for the Physical Training of Human Upper ExtremityRamos, Jorge Adrian 03 October 2013 (has links)
This thesis focuses on the development of a robotic device to be used in parallel with observational learning techniques for facilitating the recovery of the upper limb in post-stroke patients. It has been shown in the existing observational learning literature that observational practice for the execution of goal-directed single arm movements can engage the mirror neuron system and motor areas involved in learning motor actions. On the other hand, robotic-based therapy protocols have proven successful in which participants are able to learn the required perception-action skill. However, robotics have not been overly successful in the generalization of learning to other tasks and this is an essential aspect on improving performance on Activities of Daily Life (ADL). Observational learning of motor skills has been shown to produce transfer across limbs and generalization across muscle groups in the same limb, as well as transfer to perceptual tasks. Therefore, our long-term hypothesis is that a combination of interactive robotics and action observation techniques might offer a greater benefit regarding transfer to ADLs in comparison to pure robotic training.
The results from this research broaden the theoretical understanding of observational learning and drive the future development of rehabilitation protocols using the combination of robotic and observational learning techniques. We hypothesize that if the application of these techniques, for non-stroke individuals, yield benefits for the learning of motor/skill actions, then such paradigm will serve as a foundation in the future development of methods for facilitating the recovery of upper limb function after stroke.
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Excitabilité du système miroir : une étude de stimulation magnétique transcrânienne sur le chant et le langageRoyal, Isabelle 09 1900 (has links)
La perception de mouvements est associée à une augmentation de l’excitabilité du cortex moteur humain. Ce système appelé « miroir » sous-tendrait notre habileté à comprendre les gestes posés par une tierce personne puisqu’il est impliqué dans la reconnaissance, la compréhension et l’imitation de ces gestes. Dans cette étude, nous examinons de quelle façon ce système miroir s’implique et se latéralise dans la perception du chant et de la parole. Une stimulation magnétique transcrânienne (TMS) à impulsion unique a été appliquée sur la représentation de la bouche du cortex moteur de 11 participants. La réponse motrice engendrée a été mesurée sous la forme de potentiels évoqués moteurs (PÉMs), enregistrés à partir du muscle de la bouche. Ceux-ci ont été comparés lors de la perception de chant et de parole, dans chaque hémisphère cérébral. Afin d’examiner l’activation de ce système moteur dans le temps, les impulsions de la TMS ont été envoyées aléatoirement à l’intérieur de 7 fenêtres temporelles (500-3500 ms). Les
stimuli pour la tâche de perception du chant correspondaient à des vidéos de 4 secondes
dans lesquelles une chanteuse produisait un intervalle ascendant de deux notes que les
participants devaient juger comme correspondant ou non à un intervalle écrit. Pour la tâche de perception de la parole, les participants regardaient des vidéos de 4 secondes montrant une personne expliquant un proverbe et devaient juger si cette explication correspondait bien à un proverbe écrit. Les résultats de cette étude montrent que les amplitudes des PÉMs recueillis dans la tâche de perception de chant étaient plus grandes après stimulation de l’hémisphère droit que de l’hémisphère gauche, surtout lorsque l’impulsion était envoyée entre 1000 et 1500 ms. Aucun effet significatif n’est ressorti de la condition de perception de la parole. Ces résultats suggèrent que le système miroir de l’hémisphère droit s’active
davantage après une présentation motrice audio-visuelle, en comparaison de l’hémisphère gauche. / The perception of movements is associated with increased activity in the human motor cortex. This system underlies our ability to understand one’s actions, as it is implicated in the recognition, understanding and imitation of actions. In this study, we investigated the involvement and lateralization of this “mirror neuron” system (MNS) in the perception of singing and speech. Transcranial magnetic stimulation (TMS) was applied over the mouth representation of the motor cortex in 11 participants. The generated motor response was measured in the form of motor evoked potentials (MEPs), recorded from the mouth muscle. The MEPs were compared for the singing and speech conditions in each cerebral hemisphere. Furthermore, to investigate the time course of the MNS activation, TMS pulses were randomly emitted in 7 time windows (ranging from 500 to 3500 milliseconds after stimulus onset). The stimuli for the singing condition consisted in 4-second videos of singers producing a 2-note ascending interval. Participants had to judge whether the sung interval matched a written interval, previously presented on the screen. For the speech condition, 4-second videos of a person explaining a proverb were shown. Participants had to decide whether this explanation matched a written proverb previously displayed on the screen. Results show that the MEP amplitudes were higher after stimulation of the right hemisphere in the singing condition. More specifically, sending TMS pulses between 1000 and 1500 milliseconds over the right hemisphere yielded higher MEPs as compared to the left hemisphere. No effect was found in the speech condition. These results suggest that the right MNS is more activated after an audiovisual motor presentation compared to the left hemisphere.
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Sledování imitační schopnosti orofaciální motoriky u dětí do šestého měsíce života jako součást globálního motorického vzoru / Observation of the imitation capability of the orofacial motor skill as a part of a global motor model with children in the first six months of their lifeBlažková, Zuzana January 2015 (has links)
The aim of the diploma thesis was to observe the capability of imitation in orofacial area of three days old infants and analyze if the capability relates to quality of psychomotor development, thus whether it relates with a global motor model. This paper is a pilot study comprising seventeen infants. Each of them was supposed to attend four visits during the first six months of their life. It included visits in the first few days, between the fourth and the sixth week, the third month and the sixth month of their life. The psychomotor development was examined and within the first visit there was established communication with the child by means of eye contact and imitation. Each child's attempt at imitation and response was recorded. This thesis can serve as a basis for further research dealing with this topic that includes the imitation skill of mirror neurons related to psychomotor development.
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Excitabilité du système miroir : une étude de stimulation magnétique transcrânienne sur le chant et le langageRoyal, Isabelle 09 1900 (has links)
La perception de mouvements est associée à une augmentation de l’excitabilité du cortex moteur humain. Ce système appelé « miroir » sous-tendrait notre habileté à comprendre les gestes posés par une tierce personne puisqu’il est impliqué dans la reconnaissance, la compréhension et l’imitation de ces gestes. Dans cette étude, nous examinons de quelle façon ce système miroir s’implique et se latéralise dans la perception du chant et de la parole. Une stimulation magnétique transcrânienne (TMS) à impulsion unique a été appliquée sur la représentation de la bouche du cortex moteur de 11 participants. La réponse motrice engendrée a été mesurée sous la forme de potentiels évoqués moteurs (PÉMs), enregistrés à partir du muscle de la bouche. Ceux-ci ont été comparés lors de la perception de chant et de parole, dans chaque hémisphère cérébral. Afin d’examiner l’activation de ce système moteur dans le temps, les impulsions de la TMS ont été envoyées aléatoirement à l’intérieur de 7 fenêtres temporelles (500-3500 ms). Les
stimuli pour la tâche de perception du chant correspondaient à des vidéos de 4 secondes
dans lesquelles une chanteuse produisait un intervalle ascendant de deux notes que les
participants devaient juger comme correspondant ou non à un intervalle écrit. Pour la tâche de perception de la parole, les participants regardaient des vidéos de 4 secondes montrant une personne expliquant un proverbe et devaient juger si cette explication correspondait bien à un proverbe écrit. Les résultats de cette étude montrent que les amplitudes des PÉMs recueillis dans la tâche de perception de chant étaient plus grandes après stimulation de l’hémisphère droit que de l’hémisphère gauche, surtout lorsque l’impulsion était envoyée entre 1000 et 1500 ms. Aucun effet significatif n’est ressorti de la condition de perception de la parole. Ces résultats suggèrent que le système miroir de l’hémisphère droit s’active
davantage après une présentation motrice audio-visuelle, en comparaison de l’hémisphère gauche. / The perception of movements is associated with increased activity in the human motor cortex. This system underlies our ability to understand one’s actions, as it is implicated in the recognition, understanding and imitation of actions. In this study, we investigated the involvement and lateralization of this “mirror neuron” system (MNS) in the perception of singing and speech. Transcranial magnetic stimulation (TMS) was applied over the mouth representation of the motor cortex in 11 participants. The generated motor response was measured in the form of motor evoked potentials (MEPs), recorded from the mouth muscle. The MEPs were compared for the singing and speech conditions in each cerebral hemisphere. Furthermore, to investigate the time course of the MNS activation, TMS pulses were randomly emitted in 7 time windows (ranging from 500 to 3500 milliseconds after stimulus onset). The stimuli for the singing condition consisted in 4-second videos of singers producing a 2-note ascending interval. Participants had to judge whether the sung interval matched a written interval, previously presented on the screen. For the speech condition, 4-second videos of a person explaining a proverb were shown. Participants had to decide whether this explanation matched a written proverb previously displayed on the screen. Results show that the MEP amplitudes were higher after stimulation of the right hemisphere in the singing condition. More specifically, sending TMS pulses between 1000 and 1500 milliseconds over the right hemisphere yielded higher MEPs as compared to the left hemisphere. No effect was found in the speech condition. These results suggest that the right MNS is more activated after an audiovisual motor presentation compared to the left hemisphere.
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Manual Motor Development in Infancy : Execution and Observation of ActionsLjunghammar Ekberg, Therese January 2015 (has links)
Of all motor skills, manual reaching might be the one ability that matters most for infants’ perceptual, cognitive and social development. Reaching allows infants to learn about object properties, but also gives opportunities for socializing with others. The general aim of the present thesis was to study the importance of manual motor development in infancy from different perspectives; first, through examining stereopsis as a prerequisite for efficient reaching development, second, with regard to understanding others goal-directed reach actions by means of the mirror neuron system (MNS), and third, in relation to possible atypical development, with a specific focus on autism spectrum disorder (ASD). Study I shows that under monocular viewing conditions, infants at six, eight and 10 months of age perform slower and less accurate reaches. Longer times to object contact during monocular trials specifically imply that motor prediction is less effective when depth and distance information is compromised. Study II demonstrates that, by eight months of age, infants seem to have a MNS that functions in a similar manner to the adult MNS, thus activity can be registered over the motor cortex when infants simply observe an action they can master themselves. This activation is predictive, indicating anticipation of the goal of the observed reach. Study III indicates that infants at elevated familial risk for ASD present with reduced prospective motor control at 10 months of age. Compared to a low-risk control sample, high-risk infants perform reactive rather than predictive reach actions. Follow-up assessment at 36 months will show whether this measure can be used as a predictive diagnostic marker for ASD. The main contribution given by this work is the insight that it is important to take manual motor aspects into account when considering typical as well as atypical cognitive and social development, and in addition, that motor prediction is a key factor behind being able to timely execute and understand reaching actions.
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Efeito da neuromodulação em ritmo mu durante observação e mentalização de movimentos biológicos e não-biológicosLapenta, Olivia Morgan 17 August 2012 (has links)
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Previous issue date: 2012-08-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The Mental Simulation theory suggests activation of the motor network during imagery and execution of movements, similarly to the activation during observation and execution of actions, which is mediated by the Mirror Neuron System. This activation can be measured using eletroencefalography register of Mu rhythm suppression. It is propose that motor network activation and therefore increase of cortical excitability at primary motor cortex and Mu dessynchronization are due to premotor Miror-Neuron System inputs. Transcranial direct current stimulation is a neuromodulation technique that induce facilitation and inhibition of neural firing leading to enhance or decrease in cortical excitability, respectively. Thus, we propose to evaluate the polarity dependent effects of this technique in the Mu rhythm during biological and non-biological movements observation and imagery tasks. Therefore we applied anodal, cathodal and sham stimulation in 21 male subjects (mean age 23.8+3,06), over left primary motor cortex (2mA for 20min) and immediately after we registered the electroencephalography considering the electrodes C3, C4 and surrounding C3 and C4 and Cz. Analyses of C3 and C4 showed significant effects according to Movement (p=0.005), and also for the interactions between type of stimulation and hemisphere (p=0.04) and type of stimulation, movement and hemisphere (p=0.02). Surrounding electrodes analyses revealed significant effect for the interaction between stimulation type, task condition and movement type (p=0.03). Thus, the main findings of this study were i. Mu suppression for biological movement (in both imagery and observation) of the hand region in the contralateral hemisphere after sham stimulation, ii. reverse effect for the surrounding electrodes during imagery condition and iii. polarity-dependent neuromodulation of the Mu rhythm. The results are discussed considering focal ERD/ surrounding ERS according to the type of task. We concluded that there are contralateral focal Mu dessynchronization during observation and imagery of biological movements together with syncronizarion of the motor areas not involved in the task only for the imagery condition and that transcranial direct current stimulation has a significant effect under the entire electrode and according to the applied polarity. The use of transcranial direct current stimulation followed by observation and imagery tasks might be an interesting intervention strategy for disturbances involving motor ability impairment as well as deficits related to imitation and comprehension of other s actions. / A teoria de simulação mental sugere ativação da rede neural motora durante mentalização e execução de movimentos, de maneira análoga à ativação em observação e execução de ações, o que é mediado pelo Sistema de Neurônios-Espelho. Esta ativação pode ser mensurada por supressão do ritmo Mu registrado por eletroencefalografia. É proposto que a ativação de áreas motoras e, portanto, o aumento de excitabilidade cortical em cortex motor primário e a dessincronização do ritmo Mu ocorram em consequência de insumo proveniente do Sistema Neurônios-Espelho pré-motor. A estimulação transcraniana por corrente contínua consiste numa técnica de neuromodulação por facilitação e inibição de disparo neuronal levando a aumento e redução de excitabilidade cortical, respectivamente. Assim, foi proposto avaliar os efeitos polaridade dependentes desta técnica sobre ritmo Mu durante tarefas de observação e mentalização de movimentos biológicos e não biológicos. Para tal, aplicamos estimulação anódica, catódica e placebo em 21 homens destros (idade média de 23.8+3,06), sobre córtex motor primário esquerdo (2mA por 20min) e, em seguida foi feito o registro eletroencefalográfico considerando os eletrodos C3, C4 e entorno de C3 e C4 e Cz. A análise de C3 e C4 apresentou efeitos significativos quanto ao tipo de Movimento (p=0.005) e ainda quanto as interações entre tipo de estimulação e hemisfério (p=0.04) e tipo de estimulação, de movimento e hemisfério (p=0.02). A análise dos eletrodos do entorno revelou efeito significativo para a interação entre tipo de estimulação, condição da tarefa e tipo de movimento (p=0.03). Assim, os principais achados do estudo foram i. supressão de Mu para movimento biológico (em mentalização e observação) da região da mão em hemisfério contralateral após estimulação placebo, ii. efeitos inversos para eletrodos de entorno em condição de mentalização e iii. neuromodulação polaridade dependente de ritmo Mu. Os resultados de oscilação de Mu são discutidos considerando ERD focal/ ERS entorno de acordo com o tipo de tarefa. Concluímos que há dessincronização contralateral focal de Mu durante observação e mentalização de movimentos biológicos, acompanhada por sincronização de áreas motoras não envolvidas na tarefa apenas na condição de mentalização e que a estimulação transcraniana por corrente contínua tem efeito sob toda a superfície do eletrodo e difere de acordo com a polaridade aplicada. O uso da estimulação transcraniana por corrente contínua combinada com tarefas de observação e mentalização pode conferir uma estratégia interessante de intervenção em distúrbios envolvendo comprometimento das habilidades motoras bem como comprometimento de habilidades de imitação e compreensão das ações do outro.
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fMRI exploration of the cerebral mechanisms of the perception of pain in others via facial expressionBudell, Lesley 06 1900 (has links)
No description available.
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L'apprendimento motorio in persone sane e Parkinsoniane: L'effetto combinato dell'esperienza multimodale e di neurostimolazione / MOTOR LEARNING IN HEALTHY AND PARKINSONIAN ADULTS: THE COMBINED EFFECTS OF MULTIMODAL EXPERIENCE AND NEUROSTIMULATIONDI NUZZO, CHIARA 12 March 2015 (has links)
L'obiettivo principale del lavoro è stato di valutare il ruolo della neurostimolazione e della multimodalità (intesa come la presentazione visiva di un modello che esegue un movimento assieme a una musica sincrona) nell’apprendimento motorio, indagando sia gli effetti sugli adulti sani sia su pazienti affetti da Morbo di Parkinson (MP). Per raggiungere tale obiettivo, sono state condotte tre ricerche sperimentali e longitudinali, utilizzando diversi strumenti, come tDCS, biofeedback e KinectTM.
Partendo da una sistematica revisione della letteratura nel campo della riabilitazione neuromotoria, sono state identificate tre forme di trattamento che sembrano efficaci contro i sintomi motori del MP. Tuttavia, pur riconoscendo la loro efficacia, non sono mai stati combinati nella pratica riabilitativa: l’Action Observation Learning (basato sulla teoria del sistema dei neuroni specchio), la neurostimolazione anodica non-invasiva sulla zona motoria primaria e l'uso della musica.
I risultati dimostrano un chiaro sostegno della multimodalità e della neuro stimolazione nella fase di encoding e un loro supporto nel migliorare le funzioni motorie, anche a distanza di un mese. Questo lavoro offre nuove indicazioni per lo sviluppo di approcci innovativi ed efficaci nel campo dell’apprendimento motorio. / The main objective was to assess the role of neurostimulation and multimodality (namely the presentation of a visual model together with a synchronized musical track) in motor learning, by considering both healthy adults and Parkinsonian patients (PD). In order to achieve this goal, three experimental and longitudinal studies were carried out, using different tools such as tDCS, biofeedback and KinectTM.
Starting with a systematic review, three innovative approaches which seem to be effective in treating the motor symptoms of PD, were identified. However, while recognizing the effectiveness of these three promising approaches, they have never been combined: Action Observation Learning (based on the theory of mirror neuron system), the non-invasive anodal neurostimulation on the primary motor area and the use of music. The results showed a clear support of multimodality and neurostimulation during the encoding phase and in improving motor functions, even after one month. This work provides new suggestions for innovative and effective treatments in motor learning field.
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