Global ETD Search

11	Identification and characterization of a novel monooxygenase from Burkholderia xenovorans LB400 Montes-Matias, Marie Carmen. January 2008 (has links) Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Microbiology and Molecular Genetics." Includes bibliographical references (p. 120-127).
12	Probing the interactions between component B and the hydroxylase of methane monooxygenase / Wallar, Bradley James. January 2000 (has links) Thesis (Ph.D.)--University of Minnesota, 2000. / Includes bibliographical references. Also available on the World Wide Web as a PDF file.
13	Acute exposure to ethionamide in an Fmo 1/2/4 null murine model Palmer, Amy L. (Amy Leigh) 22 March 2012 (has links) The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the intestine, kidney, liver, and lung. In humans, active functional FMO21 is found in approximately 50% of Sub-Saharan Africans and a truncated, inactive FMO22, is found in all Caucasians and Asians. Polymorphisms in human FMO2 were investigated by comparing differences in metabolism of ethionamide in wildtype mice relative to Fmo 1/2/4 null mice. All mice were capable of metabolizing ethionamide into ethionamide S-oxide and 2-ethyl-4-amidopyridine. Wildtype mice had higher plasma levels of metabolites than parent compound. In contrast, Fmo 1/2/4 null mice had higher plasma levels of parent compound than metabolites. In both mouse populations, maximum ethionamide concentration peaked at 2 hours post-exposure. Increased metabolism of ethionamide in wildtype mice may deplete glutathione pools and induce oxidative stress leading to greater toxicity and adverse drug effects. This murine model is used to demonstrate the polymorphic differences of FMO2 occurring in humans. Taking these differences into account, polymorphisms of drug metabolizing enzymes provide a basis for increasing specific and individualized drug treatment regiments in susceptible populations. / Graduation date: 2012 Ethionamide FMO Monooxygenases Antitubercular agents
14	Cloning, heterologus expression, and characterization of the cytochrome P450 monooxygenases in rainbow trout (Oncorhynchus mykiss) Yang, Yea-Huey 12 December 1997 (has links) Graduation date: 1998 Rainbow trout -- Molecular genetics Monooxygenases
15	Chloroform cometabolism by butane-grown bacteria : diversity in butane monooxygenases Hamamura, Natsuko 04 September 1997 (has links) Graduation date: 1998 Chloroform -- Biodegradation Bacteria -- Metabolism Monooxygenases
16	Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora / Halsey, Kimberly H. January 1900 (has links) Thesis (Ph. D.)--Oregon State University, 2007. / Printout. Includes bibliographical references (leaves 101-116). Also available on the World Wide Web.
17	Study of two proteins involved in protein disulphide formation molecular cloning and characterization of a full-length flavin-dependent monooxygenase from Saccharomyces cerevisiae & preliminary structure analysis on DsbC from Haemophilus influenzae / Zhang, Man, January 2003 (has links) Thesis (Ph. D.)--University of Texas at Austin, 2003. / Vita. Includes bibliographical references. Available also from UMI Company.
18	Study of two proteins involved in protein disulphide formation : molecular cloning and characterization of a full-length flavin-dependent monooxygenase from Saccharomyces cerevisiae & preliminary structure analysis on DsbC from Haemophilus influenzae Zhang, Man, 1972- 27 July 2011 (has links) Not available / text Monooxygenases Saccharomyces cerevisiae Flavins Haemophilus influenzae
19	The role of vitamin D and the vitamin D receptor in TCF-4 regulation and silencing of CYP24A1 Beildeck, Marcy Ellen. January 2009 (has links) Thesis (Ph.D.)--Georgetown University, 2009. / Includes bibliographical references.
20	Control of alkane monooxygenase activity and expression in Pseudomonas butanovora / Doughty, David M. January 1900 (has links) Thesis (Ph. D.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 75-87). Also available on the World Wide Web.

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