Following the prosperity and economic growth of society, the people in Taiwan start to pay attention to the quality of hospitalization and personal health care. There are numerous new types of medical care business start to grow to meet these demands; hence the pressure of the competition in the medical care market becomes more serious ever. An immediate and important task is to utilize the knowledge and experience of the medical care workers to improve the quality of medical care service hence to create a long-term competitiveness. However, to enhance the quality of medical service, it needs to satisfy its internal customers (employees) to provide a high quality products and service. Then with high quality products and service, it will produce the satisfactory outside customers. This study focuses on the relationship between medical care industry knowledge employee¡¦s work values, motivation equality and resignation inclination. The actual survey objects are the employees of the hospitals, the pharmaceutical manufacturing and biotech related industry. This research adopts the random selection methodology for questionnaire. A total of 338 questionnaires were collected to perform the statistic analysis. The results are emphasizing the individual attributes of medical care knowledge worker to his work values, motivation equality, and resignation inclination. In summary: 1. Different individual attributes of medical care knowledge worker have significant difference in work values. 2. Different individual attributes of medical care knowledge worker have significant difference in resignation inclination. 3. Medical care knowledge workers¡¦ work values in different level have significant impact on resignation inclination. 4. Interaction between medical care knowledge workers¡¦ individual attributes and motivation equality has significant impact on resignation inclination. 5. Interaction between medical care knowledge workers¡¦ work values and motivation equality has significant impact on resignation inclination. Based on the results mentioned above, this study recommends the following suggestions to the medical care industry: (1) establish an equal and justice decision process and a transparent employee salary system, (2) enhance the mutual trust between the medical care industry and medical care workers, (3) pay attention to workers¡¦ career and development, and increase the human capital, (4) create an excellent working environment, and to allow the growth for both business and workers, (5) remove any blocks in the communication channels to create a win-win situation between medical care employer and workers. To future researchers on this topic, the author suggests that the research objectives should be expanded to the whole medical care industry. The statistical methodology should adopt the Stratified Random Sampling method. Data collection uses questionnaire mainly but complements with other observation method and in-depth interview method. There are many factors to affect the employee¡¦s resignation inclination, but only the worker¡¦s work values, motivation equality, and individual attributes to be selected as the variables. Other variables, such as organization climate, behavior of leadership, and etc.., are not included in this research. The author recommends that the future study can concentrate on the actual case study for the resignation inclination problems by using multi-variable analysis method.