This study analyzes the activities of the organized crime groups involved in the drug business, as well as examining national and international efforts to control these groups. Specifically, this study addresses the following questions: How is organized crime connected to the international drug business?; What are the major transnational organized crime groups involved in the international drug business?; What is the nature of the drug problem as it relates to organized crime internationally?; What international cooperative law enforcement efforts currently exist to deal with organized crime and the drug business? Findings indicate that efforts to create an effective international law enforcement network are needed to meet the challenges of drug trafficking and globalized crime. To date, such efforts have largely been unsuccessful.