Abstract In many institutional settings, blocking, response restriction (e.g., restraint, protective equipment), and re-direction procedures are used extensively as intervention for self-injurious behavior (SIB) and other forms of problem behavior. In the current study, a three component, multiple-schedule analysis was used to examine the immediate and subsequent effects of blocking on SIB that persisted in the absence of social reinforcement contingencies. During the first and third components the participant was in the room, alone, with no social consequences for SIB. During the second component (response restriction) the therapist sat in the room with the participant and blocked occurrences of SIB. Results indicated that, although blocking was effective in decreasing SIB while it was being implemented, subsequent effects were idiosyncratic across participants. Evidence of increased levels of SIB following blocking was observed for some participants.