This study experimentally quantified the structure-property relations with respect to fatigue of an extruded AZ61 magnesium alloy and captured the behavior with a microstructure-sensitive MultiStage Fatigue Model. Experiments were conducted in the extruded and transverse directions under low and high cycle strain control fatigue conditions. The cyclic behavior of this alloy displayed varying degrees of cyclic hardening depending on the strain amplitude and the specimen orientation. The fracture surfaces of the fatigued specimens were analyzed using a scanning electron microscope in order to quantify structure-property relations with respect to microstructural features. Correlations between particle size, nearest neighbor distance, and grain size as a function of failure cycles were quantified. Finally, a multistage fatigue model based on the structure-property relations quantified in this study was employed to capture the anisotropic fatigue damage of the AZ61 magnesium alloy.