Research related to the control of upright posture and balance has historically focussed on the lower extremities, often treating the trunk as a single, rigid segment. The principal objective of this work, therefore, was to characterize the response of the multiarticular trunk, in healthy individuals, to unexpected support surface translations. Three dimensional trunk motions were captured, in both standing and sitting, during horizontal support surface translations in 8 directions. A 4-segment model, consisting of pelvic, lumbar, upper and lower thoracic segments, was used for all kinematic and kinetic analyses. Electromyographic (EMG) data was simultaneously acquired, bilaterally, from 7 trunk muscles and 1 hip muscle.[...] / La recherche liée au maintien de l'équilibre s'est historiquement concentrée sur les membres inferieurs, traitant souvent Ie tronc comme un segment unique et rigide. L'objectif principal de ce travail était donc, de caractériser la réponse du tronc multi articulaire chez les individus sains, suite a un mouvement inattendu de la surface de support. Le mouvement tridimensionnel du tronc a été capture durant les mouvements horizontaux de la surface de support dans 8 directions, en position debout et assise. Un modèle du tronc comprenant Ie bassin, un segment lombaire, et des segments thoraciques inferieur et supérieur, a été utilise pour les analyses cinématiques et cinétiques. Des données electromyographiques (EMG) bilatérales de 7 muscles du tronc et d'un muscle de la hanche ont été acquises simultanément.[...] fr

The voltage-gated chloride channel, ClC-1, a member of the CLC family of proteins, is expressed predominantly in skeletal muscle cells. In this tissue, ClC-1 contributes to repolarisation and stabilisation of the membrane potential after an action potential. In the absence of ClC-1 function, voltage-gated sodium channels can recover from inactivation before the membrane potential has returned to resting levels, and hence can reopen without further stimulus, resulting in a run of contractions. Clinically, this phenomenon leads to the muscle stiffness disease myotonia. Members of the CLC family of proteins have been identified in many species from bacteria to mammals, and the X-ray crystallographic structure of a bacterial member of this family revealed a complex structure with 17 intramembrane helices. These proteins exist as a functional dimer, with a separate permeation pore within each subunit. There appears to be two separate gating mechanisms; the fast gate which acts on each pore independently and the slow or common gate operating on both pores simultaneously. The aim of this study was to identify functionally important regions within the ClC-1 channel, with the ultimate aim of elucidating the mechanisms involved in gating. / Thesis (PhDHealthSciences)--University of South Australia, 2006.

Thesis (PhD) -- University of South Australia, 1998

Thesis (Ph. D.)--University of Toronto, 2006. / Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3271. Includes bibliographical references.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographic references (leaves [126]-138).

Thesis (Ph. D.)--Ohio State University, 2004. / Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 2.

Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 285-294). Available also in a digital version from Dissertation Abstracts.

Thesis (M.Sc.)--York University, 2006. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 69-74). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR29558

Thesis (M.S.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains viii, 119 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 97-101).