The aim of this study is to design and build a miniature spray cooling system, in which the manufactured and adopted chamber, pump and heat exchanger are smaller than the conventional ones. An experiment was conducted to explore the cooling performance of the spray cooling system after its size has been minimized. In the experiment, copper was used to make the heated surface and different working media, such as DI water, as nanofludics with silver and multi-walled carbon nanotubes powder were sprayed on the heated surface to enhance the heat dissipation efficiency of the system. The experiment in this study was set according to two conditions: transient and steady state, with Weber number as the main parameter, to observe the boiling phenomenon of different working media on heated surface and to record the temperature changes of the heated surface. The results were shown in boiling curve and cooling curve. The ultimate goal of this study was to obtain a better understanding of the cooling performance of the miniature spray cooling system in order to apply it to micro-electronic cooling devices, thereby solving the problem of the sharp increase in heating power per unit area on electronic components.