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No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Annelise_Fran?a_Ara?jo.pdf: 2722328 bytes, checksum: 24fe96c2c5e7a6dd79e50d8862a82e63 (MD5) Previous issue date: 2016 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Funda??o de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) / RESUMO Nanopart?culas bimet?licas de Fe-Ni estabilizadas com carboximetilcelulose (CMC-bNP-Fe-Ni) foram sintetizadas, caracterizadas e aplicadas na remo??o dos f?rmacos nimesulida (NMS) e ranitidina (RNTD) em ?gua. Para os ensaios em batelada em solu??es aquosas fatores que afetam a remo??o dos f?rmacos tais como a sua concentra??o e a dosagem de CMC-bNP-Fe-Ni foram investigados sistematicamente. Os resultados experimentais revelaram uma remo??o completa de NMS e de 84% de remo??o de RNTD. Como esperado para uma rea??o heterog?nea realizada em batelada, sob vigorosa agita??o, foi verificado que a taxa de remo??o aumentou com o aumento da dosagem de CMC-bNP-Fe-Ni e a concentra??o dos f?rmacos. Foi realizado um estudo do efeito da velocidade de agita??o do sistema, verificando que este ? um fator que influencia diretamente a taxa de remo??o. O estudo de remo??o na presen?a e na aus?ncia de oxig?nio dissolvido revelou que a presen?a deste exerceu uma pequena influ?ncia no processo de remo??o. Um estudo comparativo utilizando a CMC-bNP-Fe-Ni e a carboximetilcelulose (CMC) como estabilizante de nanopart?culas de ferro de val?ncia zero (CMC-nFZV) foi realizado nas mesmas propor??es, sendo verificado que os n?veis de remo??o foram superiores para o sistema CMC-bNP-Fe-Ni. A an?lise do subproduto formado da NMS mostrou que este ? menos t?xico que o composto original. O presente trabalho demonstra que o processo de tratamento redutivo alternativo fazendo uso de nanopart?culas bimet?licas contendo Fe e Ni ? muito promissor para a elimina??o de f?rmacos, como ? o caso de NMS e RNTD. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Qu?mica, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2016. / ABSTRACT Fe-Ni bimetallic nanoparticles stabilized with carboxymethylcellulose (CMC-bNP-Fe-Ni) were synthesized, characterized and applied to remove nimesulide drugs (NMS), and ranitidine (RNTD) drugs in water. For the test batch in aqueous solutions, factors affecting the removal of drugs such as the dosage of CMC-bNP-Fe-Ni and the concentration of NMS and RNTD were investigated systematically. The experimental results showed a complete removal of NMS and 84% for the RNTD at concentrations ranging up to 60 mg L-1 and at a dosage of CMC-bNP-Fe-Ni 0.2 and 0.4 g L-1, respectively. As expected for a heterogeneous reaction carried out in batch, under vigorous stirring, it was found that the removal rate increased with the increase of the dosage of CMC-bNP-Fe-Ni and concentration of the drugs. A study of the effect of system stirring speed was carried out by checking that this is a factor that directly influence the removal rate. The removal of the presence and in the absence of dissolved oxygen showed that the presence of the latter exerts a small influence on the removal process. A comparison of removal using CMC-bNP-Fe-Ni and carboxymethylcellulose (CMC) as a stabilizer of zero-valent iron nanoparticles (CMC-nFZV) was performed in the same proportions, and found that the removal rates were higher for system CMC-bNP-Fe-Ni. The analysis of the byproduct formed from the NMS showed that it is less toxic than the parent compound. The present work demonstrates that the reductive treatment process alternative making use of bimetallic nanoparticles containing Fe and Ni is very promising for the elimination of drugs, such as NMS and RNTD.