Global ETD Search

1	IRONSperm: Sperm-templated soft magnetic microrobots Magdanz, Veronika, Khalil, Islam S. M., Simmchen, Juliane, Furtado, Guilherme P., Mohanty, Sumit, Gebauer, Johannes, Xu, Haifeng, Klingner, Anke, Aziz, Azaam, Medina-Sánchez, Mariana, Schmidt, Oliver G., Misra, Sarthak 22 July 2022 (has links) We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. info:eu-repo/classification/ddc/621.3 ddc:621.3
2	Engineering microrobots for targeted cancer therapies from a medical perspective Schmidt, Christine K., Medina-Sánchez, Mariana, Edmondson, Richard J., Schmidt, Oliver G. 22 July 2022 (has links) Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies. info:eu-repo/classification/ddc/621.3 ddc:621.3
3	Controlled manipulation of multiple cells using catalytic microbots Sanchez, Samuel, Solovev, Alexander A., Schulze, Sabine, Schmidt, Oliver G. 31 March 2014 (has links) (PDF) Self-propelled microjet engines (microbots) can transport multiple cells into specific locations in a fluid. The motion is externally controlled by a magnetic field which allows to selectively load, transport and deliver the cells. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. autonome Bewegung Nanomotor Mikromotor Nanorotor Transport Nanoröhre Fracht autonomous movement nanomotors microengines nanorotors nanorobots transport nanotubes cargo ddc:540 rvk:VA 1120
4	Controlled manipulation of multiple cells using catalytic microbots Sanchez, Samuel, Solovev, Alexander A., Schulze, Sabine, Schmidt, Oliver G. January 2011 (has links) Self-propelled microjet engines (microbots) can transport multiple cells into specific locations in a fluid. The motion is externally controlled by a magnetic field which allows to selectively load, transport and deliver the cells. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. info:eu-repo/classification/ddc/540 ddc:540

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