In the present study, we examined ethnic variables (viz., multigroup ethnic identity and other group orientation) along with negative life events as predictors of depressive symptoms and suicidal behaviors in a sample of 156 (38 male and 118 female) Latino college students. Results of conducting hierarchical regression analyses indicated that the set of ethnic variables accounted for significant variance in both depressive symptoms and suicidal behaviors. The inclusion of negative life events was found to account for significant additional variance in both outcomes, beyond what was accounted for by ethnic variables. Interestingly, beyond main effects, results indicated a significant Other Group Orientation × Negative Life Events interaction effect to account for additional variance in depressive symptoms and suicidal behaviors. Some implications of the present findings are discussed, including the potential value for Latinos to broaden their attitudes and interactions with other ethnic groups.