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Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic strokeKhan, A., Kamran, S., Akhtar, N., Ponirakis, G., Al-Muhannadi, H., Petropoulos, I.N., Al-Fahdawi, Shumoos, Qahwaji, Rami S.R., Sartaj, F., Babu, B., Wadiwala, M.F., Shuaib, A., Mailk, R.A. 26 November 2018 (has links)
Yes / Endothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We
undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve
morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control
participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001)
and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve
branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute
ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter
correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017,
P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent
association between corneal endothelial cell density, area and perimeter with acute ischemic stroke
and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to
identify patients at risk of acute ischemic stroke. / Qatar National Research Fund Grant BMRP20038654
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