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EFFECTS OF ELECTRICAL STIMULATION ON THE RECRUITMENT ORDER OF MOTOR UNITS IN MAN: INDIRECT EXAMINATION BY ELECTRICALLY EVOKED MUSCLE RESPONSESTrimble, Mark Herbert, 1958- January 1987 (has links)
Although the neural mechanisms responsible for the orderly recruitment of motor units have been investigated extensively, the flexibility of the underlying neural circuitry remains unclear. For example, the effects of electrical stimulation on the recruitment order of motor units is not well understood. This project was designed to study the recruitment order of motor units in man during different stimulation protocols. Examination of the compound-twitch characteristics of electrically evoked responses allowed an indirect determination of motor-unit recruitment order. The results demonstrate that the recruitment order of quadriceps femoris and triceps surae motor units differs according to the stimulation protocols used. Analysis of the compound-twitch characteristics indicated that the recruitment order of motor units during Hoffmann reflexes is similar to that of volitional muscle contractions but effectively the reverse of that during direct-motor responses. Moreover, the results suggest that cutaneous-afferent stimulation alters the recruitment thresholds of different motor unit types during the Hoffman reflex.
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Peptidergic regulation of visceral motor circuits in the Sea Hare, Aplysia californicaMorgan, James L. M. 04 June 1991 (has links)
Graduation date: 1992
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The role of postsynaptic muscle fibers in maintenance and repair of mammalian neuromuscular junctionsLi, Yue, 1977- 28 August 2008 (has links)
Previous studies from our lab showed that terminal Schwann cells (TSCs) are actively involved in the restoration of functional synapses during reinnervation at mammalian neuromuscular junctions (NMJs). However, it is unclear what induces TSCs to extend processes that guide the nerve growth (Son and Thompson, 1995a,b). Is it the loss of the axon or instead, some signal arising from denervated muscle fibers? The main objective of my dissertation was to examine whether muscle fibers can be the source of signals affecting TSC growth. In Chapter 2, I report that both TSCs and nerve terminals are maintained at the former junction even after their underlying muscle fiber degenerates. Some of the original AChRs are surprisingly sustained at the synaptic sites for a long time with the preserved pretzel pattern. These results show that the postsynaptic target is not necessary for the maintenance of presynaptic structures. In Chapter 3, I report that following fiber regeneration, newly formed AChRs are clearly separated from the persisting receptors at most locations and they are apposed by the nerves. Moreover, as the fiber regenerates, TSCs begin to grow processes. Nerve sprouts then follow these processes to form new synaptic sites beyond the old receptor territory. My observations therefore show that signals for nerve growth arise from regenerating fibers and they appear to act by first affecting TSCs. Such signals seem diffusible because I saw that TSCs on surrounding fibers also began to grow during regeneration. In Chapter 4, I report that new junctions on the regenerated fibers are very dynamic. They undergo continual remodeling and eventually take on an 'en grappe' pattern. Since the synapses on undamaged fibers are normally very stable, these observations suggest that regeneration has set in place a process whereby the synapses are unable to stabilize. Interestingly, this appears to be the case in muscles that degenerate as a consequence of muscular dystrophy. My findings are important because they suggest an active role of the postsynaptic muscle fiber not in synapse maintenance but rather in generating signals that attract innervation after injury. / text
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Dynamics of the nervous system in the upper limb tension test :Zorn, Patricia M. Unknown Date (has links)
Thesis (MAppSc in Physiotherapy)--University of South Australia, 1995
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Transmission in adrenergic neurones : storage and release of the sympathetic transmitterGeffen, Laurence January 1966 (has links)
No description available.
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DESIGN FEATURES OF THE SEGMENTAL MOTOR CONTROL SYSTEM: THE EFFICACY OF MONOSYNAPTIC SPINDLE IA CONNECTIONS ONTO THEIR HOMONYMOUS MOTONEURONS (EPSP, SPINAL CORD, COMPOSITE, NEUROPHYSIOLOGY).Vanden Noven, Sharyn January 1984 (has links)
In the field of spinal-cord neurophysiology, the nature of and the rules which govern the strength of functional connections between muscle afferents and motoneurons supplying the same muscle are important to delineate. This study addressed a facet of this issue by testing the possibility that the strength of the spindle Ia-motoneuronal connections is stronger (as demonstrated by the differing amplitudes of the mean maximum composite Ia EPSPs) if both neurons supply the same sub-volume of the muscle, providing the various sub-volumes of the muscle are capable of independent action. Intracellular recordings were made of the Ia EPSP responses of semimembranosus (SM) and lateral gastrocnemius (LG) motoneurons in anesthetized low-spinal cats to electrical stimulation (Group I range) of nerve branches supplying different parts of the homonymous muscle, as well as different heteronymous muscles. For study of SM motoneurons, stimulated nerve branches included those supplying the anterior (SMa) and posterior (SMp) heads of the SM muscle and three providing heteronymous input from the anterior (BFa) and posterior (BFp) parts of biceps femoris and the distal part of the semitendinosus (STd) muscle. Ia EPSPs were partitioned such that stimulation of the SMa nerve branch produced significantly larger EPSPs in SMa motoneurons than in SMp cells; likewise, stimulation of the SMp nerve branch produced larger EPSPs in SMp motoneurons than in SMa cells. Study of the differences in the strength of heteronymous Ia input (i.e., from BFa, BFp and STd) between the SMa and SMp cell groups correlates with the different actions reported previously for the two heads of the SM muscle. For study of LG motoneurons, the stimulated nerve branches were those supplying the four neuromuscular compartments of the LG muscle (LG1, LG2, LG3 and LGm) and the nerve to a heteronymous muscle, soleus (SOL). In all five instances, partitioned Ia effects were evident. An association is suggested between the present results and previous electromyographic studies. The previous studies have shown that the muscle heads (SM) or neuromuscular compartments (LG) under consideration in this study are capable of somewhat separate actions. The present study also included assessment of the relative extent to which the partitioned Ia effects could be attributed, in part, to one or two developmental factors, topographic specificity and species specificity. The analysis suggested that both factors were potentially implicated, with species specificity somewhat predominant over topographic specificity.
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A comparative investigation of the pharmacology of fish and mammalian neuromuscular systemsGant, Daniel B. 28 October 1985 (has links)
Graduation date: 1986
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Cellular behaviors regulating tangential migration of facial branchiomotor neurons in the zebrafish embryoSawant, Anagha. Chandrasekhar, Anand, January 2009 (has links)
The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 20, 2010). Thesis advisor: Dr. Anand Chandrasekhar. Includes bibliographical references.
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Interconnections between the hand and face representations in the human motor systemChan, Chung-yan, Tommy, 陳頌恩 January 2002 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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ASSESSMENT OF SYNCHRONOUS ACTIVITY BETWEEN NEURONAL SIGNALSRoscoe, Dennis Don January 1980 (has links)
Many recent studies on the segmental motor control system have employed spike-triggered-averaging (STA) and other forms of cross-correlation to either attribute CNS, reflex, or direct motor effects to the impulses of a single (reference) neuronal spike train or to explore conditions under which pairs of neural units show temporal correlations in their discharge. Our experience with these techniques suggested the need for a control procedure that tests for synchrony between the reference and other spike trains such as to: (1) either preclude that the observed effects are due to spike trains other than or in addition to the reference train; or (2) give insight into the conditions leading to correlated discharge between two units. A motor unit synchronization test based on analysis of EMG waveforms has already been described. We have modified this test for the detection of synchrony between either afferent or efferent signals by analysis of averaged muscle nerve signals rather than EMG waveforms. Our procedure involves use of a multi-unit muscle nerve recording that serves as the input to a signal averager triggered by a spike train from either: (1) a motor unit's EMG; (2) a dorsal root filament or ganglion cell; or (3) a ramdom trigger source. With appropriate delay of the muscle nerve signal input, the non-rectified average of the trigger signal's waveform is compared to the rectified average which contains this waveform together with contributions of all other active unitary events. Additionally, the rectified average is compared to a "randomly" triggered average of the same input signal. On the basis of these recordings, it can be determined, within certain boundary conditions, whether or not any other unitary events are in synchrony with the reference event. Such synchronization is expressed quantitatively in the form of a synchronization index (SI). We evaluated the efficacy of the SI by electronic simulation procedures and by comparing its use to that of a cross-correlation procedure that tests for synchrony on the basis of crosscorrelograms computed between two simultaneously recorded spindle afferent spike trains during brief stretch of a passive muscle at progressively increasing amplitudes (5 - 100um). These experiments revealed that the SI is a sensitive test of afferent synchrony in the passive muscle provided the spike trains of interest have a signal-to-noise (S/N) ratio > 0.2 in the muscle nerve recording and that it is recognized that the detectable degree of synchronization of a non-reference event is a function of its S/N ratio. For tests on the active muscle, the force levels must remain low. Otherwise increased neuronal activity in the muscle nerve recording decreases the S/N ratio of individual spike trains. Thus, despite restrictive (but predictable) boundary conditions, the SI test can contribute importantly to select conclusions drawn from cross-correlation studies.
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