No description available.

BACKGROUND. Neuropathological processes affecting the left frontotemporal lobes and their connections with subcortical structures have been reported in individuals who sexually assault minors. However, these findings are not necessarily conclusive, and knowledge is limited as to how such factors influence the 'blocking' adult sexual relations, disinhibition, emotional congruence and sexual arousal to children; or indeed if functional disorders are more significant. METHOD. A combination of neuropsychological (LNNB Form II) and personality (MMPI-2) probes where used to ascertain the profiles of male subjects satisfying DSM-III criteria for paedophilia, and a comparison was made with male rapist and homicide offenders to identify a characteristic neuro-behavioural syndrome. All groups were matched for premorbid intelligence, drug/alcohol abuse, socio-economic status and incarceration period. Hypotheses of greater dysfunction localised to the lefthemisphere fronto-temporal lobe areas, and more disturbed personality and psychopathology in the paedophile offenders were tested. The Multiphasic Sex Inventory (MSI) was also used to confirm the diagnoses of the sexual offenders and to assess psychosexual functioning. RESULTS. The offender groups were undifferentiated in terms of frequency of overall neuropsychological dysfunction, yet 26.8 per cent had clinically significant cognitive impairment, and a further 23.2 per cent were diagnosed as 'Borderline.' However, pattern of expressive speech and writing deficits in the paedophile group's LNNB-11 profile was consistent with subclinical features of Transcortical Motor Aphasia-Type I syndrome (i.e. non-fluent verbal output - decreased spontaneity of expression and impoverished narrative speech, but with intact comprehension, repetition of spoken language; clumsily produced letters and hypereconomy of written content; and apathy). Damage to the left-hemisphere dorsolateral prefrontal cortex (DLPFC) is known to be associated with this type of aphasia, which in tum increases the probability of dysexecutive syndrome (i.e. limited planning and maintenance of goal-directed behaviour and behavioural flexibility). The impact of this syndrome was clearly reflected by socialdeficit type features found in the paedophile's MMPI-2 48' /84' profile which are consistent with a schizotypal personality disorder (i.e. apathy, social withdrawal, constricted affect, odd speech and behaviour). Additionally, psychosexual functioning, rationalisations and cognitive distortions relating to offence behaviours was found to be more deviant in paedophiles than rapists. CONCLUSION. From a developmental perspective, neuropathology of the circuits connecting the dorsolateral prefrontal cortex with sub-cortical areas, presenting as dysexecutive syndrome, may be significant in explaining the paedophile' s lack of adjustment to, indifference for, and alienation from the adult world; increasing the probability for emotional and sexual dependency on children. Several possibilities for future research are identified and practical uses for the findings of this study are presented.

Refer to document

No description available.

<p>Wilson's disease (WD), bepatolenticular degeneration, is an autosomal recessive disorder caused by mutations in the ATP7B gene, and is characterised by abnormal metabolism and deposition of copper in the liver, brain and other organs. The main aim of this thesis was to investigate the occurrence of psychopathology, as well as personality traits and neuropsychological function in Swedish patients with treated WD. The research subjects were 29 patients with confirmed WD, investigated at the Department of Internal Medicine at Uppsala University Hospital between 1996 and 2000. </p><p>The treated WD patients showed prominent psychopathology as determined by the Comprehensive Psychopathological Rating Scale. The spectrum of psychopathological symptoms is not typical of classic psychiatric syndromes, and includes symptoms from Anxiety, Depression and Obsessive-Compulsive disorders as well as Negative Symptoms. In self-assessment, the WD patients tended to underestimate the presence of psychopathological symptoms. The treated WD patients differed in their sleep pattern from the control group, as measured with the Uppsala Sleep Inventory. The spectrum of self-reported symptoms suggests an altered REM sleep function. </p><p>The treated WD patients had significant deviations in personality traits, especially in aggressivity-hostility related scales and Psychic anxiety, compared to healthy controls, as measured with the Karolinska Scales of Personality. The deviations were not related to age, age at onset or duration of WD. The treated WD patients displayed a specific profile of moderate neuropsychological impairment, as determined by the Automated Psychological Test battery. Finally, an attempt was made to search for, possible genotype-phenotype relationships in some ATP7B mutations. </p>

Wilson's disease (WD), bepatolenticular degeneration, is an autosomal recessive disorder caused by mutations in the ATP7B gene, and is characterised by abnormal metabolism and deposition of copper in the liver, brain and other organs. The main aim of this thesis was to investigate the occurrence of psychopathology, as well as personality traits and neuropsychological function in Swedish patients with treated WD. The research subjects were 29 patients with confirmed WD, investigated at the Department of Internal Medicine at Uppsala University Hospital between 1996 and 2000. The treated WD patients showed prominent psychopathology as determined by the Comprehensive Psychopathological Rating Scale. The spectrum of psychopathological symptoms is not typical of classic psychiatric syndromes, and includes symptoms from Anxiety, Depression and Obsessive-Compulsive disorders as well as Negative Symptoms. In self-assessment, the WD patients tended to underestimate the presence of psychopathological symptoms. The treated WD patients differed in their sleep pattern from the control group, as measured with the Uppsala Sleep Inventory. The spectrum of self-reported symptoms suggests an altered REM sleep function. The treated WD patients had significant deviations in personality traits, especially in aggressivity-hostility related scales and Psychic anxiety, compared to healthy controls, as measured with the Karolinska Scales of Personality. The deviations were not related to age, age at onset or duration of WD. The treated WD patients displayed a specific profile of moderate neuropsychological impairment, as determined by the Automated Psychological Test battery. Finally, an attempt was made to search for, possible genotype-phenotype relationships in some ATP7B mutations.

Traumatic brain injury (TBI) is a multi-faceted disease that affects individuals on physical, cognitive and emotional levels. The specific aims of this research are to explore the prevalence of depression and the relationship between depression, neuropsychological performance and clinical variables in a cohort with TBI. This is accomplished through the retrospective review of 75 neuropsychological reports containing information on clinical variables, performance on neuropsychological measures and Beck Depression Inventory- Second Edition (BDI-II) scores of individuals who had sustained a TBI. The neuropsychological domains assessed via the standardized neuropsychological measures were the domains of attention, concentration, memory, learning, non-verbal and abstract reasoning, manual dexterity, verbal recall, working memory, perception, psychomotor performance, incidental learning, concept formation and verbal fluency. These results were statistically analysed to determine relationships with depression and clinical variables. The investigations undertaken in this study signified particularly pertinent relationships in the interactions among the variables of interest. Higher education level was found to be extremely critical in assisting retention of cognitive abilities following a TBI. Primary language was also a significant differentiator of performance among tests. Age had contrasting effects, with increasing age being favourable on the Similarities Test and related to poorer performance on the Letter Cancellation Test. Increasing GCS scores were related to slower performance on the Letter Cancellation Test and decreased performance on the RAVLT Free Recall Test. Longer PTA duration was related to worse performance on the Matrix Reasoning Test. These results indicate that these indicators of injury severity did not correlate with cognitive performance in this sample after TBI. The high incidence of depression in this study confirms that major depression is a very common occurrence after TBI. This has widespread implications for patient and family counselling, and psychotropic interventions in treatment planning after TBI. Further research on the emotional and cognitive aspects of TBIs within the South African population is needed to supplement the lack of information currently available. It is recommended that further studies build on the current study by exploring larger samples, and using more stratification specificity in terms of the type of injury sustained as well as functional outcomes. Copyright / Dissertation (MA)--University of Pretoria, 2010. / Psychology / unrestricted

No description available.