As <i>in vivo</i> study of the alteration of the erythrocytes from forty-six young chickens of various breeds infected with tree strains of Newcastle disease virus has been made. Three strains of Newcastle disease virus which varied in their pathogenicity for chickens, namely B1, N1, and N2 strains, have been studied, comparing the agglutinability of the red blood cells by the tube hemagglutination method and the rapid-plate technique. Graphs and tables have been prepared showing the <i>in vivo</i> effect of the virus strains on the chicken crythroeytes when the viral strains are used as the agglutinating agent. By mixing a drop of whole blood with 0.05 ml. of the B1 strain of Newcastle disease virus formalized with 0.10% formalin it may be possible to diagnose Newcastle disease in chickens, without the aid of the standard hemagglutination-inhibition (HI) test. The author believes that with more study the plate method may be of real value as a screening or presumptive test in the diagnosis of Newcastle disease infection. / M.S.

Call number: LD2668 .T4 1948 L5 / Master of Science

No description available.

Thesis (MMedVet (Altil)) - University of Pretoria, 2002. / Includes bibliographical references.

Call number: LD2668 .T4 1967 S52 / Master of Science

Call number: LD2668 .T4 1955 M38 / Master of Science

Call number: LD2668 .T4 1965 K48 / Master of Science

No description available.

Thesis (Ph.D.)(Zoology)--University of Pretoria, 2007. / Includes summary. Includes bibliographical references. Available on the Internet via the World Wide Web.

Meningioma is one of the most commonly diagnosed intracranial tumors in dogs and humans. Treatment failures resulting in local recurrence and death remain common in tumors of high grade, prompting a need for additional therapeutic options that are both effective and affordable. Genetic modification of the LaSota strain of Newcastle Disease Virus (rLAS) has allowed the virus' fusion protein cleavage site to be replaced with that belonging to urokinase plasminogen activator (rLAS-uPA). This site is cleavable exclusively by the uPA receptor (uPAR), which is overexpressed in canine meningioma. The rLAS-uPA represents a targeted therapy that has the potential to be efficacious against meningioma when administered systemically. A Phase I clinical trial was designed to evaluate the safety and preliminary efficacy of rLAS-uPA administered to dogs with presumptive intracranial meningioma. The primary endpoint was to define the safety of rLAS-uPA, as determined by serial clinical and laboratory assessments during and after viral administration, using standard toxicity metrics defined by the Veterinary Cooperative Oncology Group (VCOG). Secondary end-points included anti-tumor activity quantified by magnetic resonance imaging (MRI) assessment of tumor size, and characterization of immune responses to the rLAS-uPA. Four dogs completed the trial without significant toxicity. No objective tumor responses were noted on MRI from any dog. All dogs produced antiviral antibodies and increased circulating cytokines during the course of treatment. No virus was recovered from plasma, urine, or cerebrospinal fluid. These results indicate that further investigation into the rLAS-uPA dose intensity and interval are required to further develop this therapy. / Master of Science / The use of a modified Newcastle Disease Virus intravenous infusion to treat brain tumors in dogs has been shown to have no overt significant adverse effects. However, further investigation is required to determine the efficacy and optimal dosing protocol for this potential treatment.