This study used ethnographic and qualitative research methods to provide data-driven support for the use of next-of-kin interviews to enhance overdose fatality review (OFR) datasets. This study's community of practice is a group of substance-use professionals that use OFRs to share confidential data and monitor Lucas County, Ohio substance use trends. To analyze OFR data collection, un-silo information, and understand how to include next-of-kin (NOK) interviews in the dataset, this study used rapid analysis, semi-structured interviews, and virtual participant observation methods. Rapid analysis showed current methods sufficiently collected demographic, vital statistics, and postmortem data from coroner reports; however, NOK interviews supplied narrative-derived information often missing or inconsistent in the dataset. Interviews with the community of practice and decedents' NOK showed dissonance between the two's perceptions of overdoses in Lucas County. Participants discussed themes, e.g., stigma, burnout, strained resources, and increasing fentanyl contamination-related overdoses. NOK needed accessible web-based resource options, linkages to current programs or services, stigma-free harm reduction education, and opportunities to form connections. Professionals explained the impact of widespread mental health problems, extreme social isolation, and economic pressures on overdose prevention during COVID-19. Potentially contaminated illicit substance use increased during the pandemic, overburdening the community of practice and straining already limited overdose prevention resources. Accessible, up-to-date information and web-based community engagement will encourage professionals to form connections with community members, increase fair access to information currently siloed, and provide a consolidated location to find resources and opportunities for connections within the community.