This is a study of the Qua Iboe Mission from 1887-1945. The Mission commenced in 1887 under Samuel A. Bill in response to an invitation from the Ibeno Chiefs of the Ibeno who lived as fishermen and traders on the mud and sand flats East and West of the Qua Iboe River's mouth in South East Nigeria. It was established at Obarekan in 1888 where it continued until the Ibeno people, for the most part became Christian by 1907. Bill and Mission Headquarters moved up river to Nditea in that year, where the Mission in its outreach at Nditea failed. Bill returned to Obarekan in 1928. Bill's colleague, Bailie, settled among the Ibibio in 1894 uninvited, forcing himself upon the Ibibio with the support of the African Association traders. His missionary efforts, which were considerable, failed. Kirk's entry to Etinan, further inland in 1898 was negotiated by a leading Chief and became so successful as to establish that centre of burgeoning Christianity as the Headquarters, de facto of the Mission. It is concluded that the Mission's success was due to having been first on the scene, secured by comity arrangements and the desire of the Ibeno, Ibibio and Igbo to obtain every possible advantage for their total well-being in the new order of things. Appendices, primary and secondary sources used form the completion of this work and provide data for a critical examination of its results.