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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Intravenous Regional Limb Perfusion with Butorphanol Tartrate as an Alternate Route for Analgesia in the Equine Patient

Crabtree, Naomi Elisabeth 03 May 2019 (has links)
Pain management options for the equine orthopedic patient are limited and can have harmful systemic effects. Methods of local drug delivery such as intravenous regional limb perfusion (IVRLP) are able to provide more focal therapy with a decreased risk of systemic side effects. The primary goal of the present study was to develop a novel, targeted pain management approach able to mitigate the complications encountered with systemic opioid administration. There were two main objectives with respect to elucidating the usefulness of a butorphanol IVRLP. The first of these was to evaluate the feasibility of IVRLP to deliver butorphanol to the treated limb, and the second was to develop a method for evaluating the analgesic efficacy of the procedure. The findings suggest butorphanol IVRLP is well tolerated, results in measurable levels of butorphanol in the treated limb and may be of analgesic benefit.

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