Nosocomial infections present an important health problem with morbidity, and high mortality, prolongation hospital days, and increased direct costs of patient care. This article was conducted in a general hospital in order to determine the cost of nosocomial infections and increased length of hospitalization of it. The conclusion was that the high economic expense which nosocomial infection represents justifies measures to control this entity. Nosocomial infections are a major part of the problem of reemerging pathogens causing infectious diseases, affecting 5% of hospitalized patients. Provided an enhanced, integrated infection control program, it could be assessed that the medical and economic effects on the overall nosocomial infection will lower of actual health care costs by ¢C28000NTD each case of the intervention.