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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Design of Multi-Stable Nucleic Acid Sequences

Abfalter, Ingrid G., Flamm, Christoph, Stadler, Peter F. 01 October 2018 (has links)
RNA molecules that can fold into two or more predefined alternative metastable structures can be designed rationally. We outline an algorithm for this task that reduces the problem to vertex coloring the union of all prescribed outerplanar secondary structure graphs. Starting from an ear decomposition of this composite graph colorings are produced by a dynamic programming procedure. Sequences can then be optimized for particular properties by means of standard optimization heuristics.

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