This study examined to what extent the biological sex of the nurse-physician interactants affects the interpersonal communication satisfaction experienced by the nurse. Hypotheses One and Two predicted that communication satisfaction would differ significantly across various combinations of sex of nurse and sex of physician dyads. Hypothesis Three predicted that male nurses would experience higher levels of communication satisfaction than would female nurses. Interpersonal communication satisfaction was operationalized by two self-report instruments. The sample included 153 male and female nurses. Results indicated that same-sex interactions were more satisfying for female nurses, while mixed-sex interactions were more satisfying for male nurses. Nurses reported greater communication satisfaction when interacting with female physicians. Hypothesis three was not supported.