The quality of the physical workspace environment has been widely debated in research and corporate communities. Inadequate workspace conditions have been associated with elevated levels of work-related stress, productivity, and job satisfaction. However, scholarly literature offers very little on the relationship between workspace and office placement, and workforce productivity and wellbeing. The purpose of this non-experimental quantitative study was to examine the impact of customized workspace and strategic office placement on work related stress, productivity, and job satisfaction. Optimal distinctiveness theory and cognitive-motivational-relational theory provided the theoretical framework for this study. Nine research questions in this study were designed to identify any statistically significant difference in any of the three dependent variables(work-related stress, productivity, job satisfaction) in relation to workspace design and office placement. The Work Stress Scale, Individual Work Performance Questionnaire, and the Brief Index of Affective Job Satisfaction served as data collection instruments. Data were collected from a convenience sample of 131 male and female full-time employees from 5 different organizations nationwide. With a 2x2 causal-comparative research design, a multivariate analysis of variance was conducted, which showed statistically significant difference on work-related stress and job satisfaction in relation to workspace design with no statistically significant difference for the remaining seven research questions. This study offers significant insight into best practices for ensuring the highest quality of workspace environment to enable optimal employee performance along with improved overall wellbeing.