Le cancer est une pathologie que l’on se doit de détecter le plus tôt possible si l’on veut accroître les chances de guérison. Ces travaux étudient l’apport de la signature polarimétrique à la caractérisation et l’identification des tissus cancéreux. Il s’agit d’extraire des images multidimensionnelles de polarisation des informations physiques qui caractérisent les constituants de l’objet bien au-delà de l’information visuelle des images d’intensité. Durant cette thèse, un imageur de Mueller, POLARIS, a pu être mis en place ainsi que les outils de traitement et de calibration adaptés. Une méthode de segmentation d’images de Mueller en condition d’éclairement non homogène a été proposée. Une première base d’images multi-spectrales polarimétriques de tissus sains et pathogènes chez la souris a été constituée. Une approche originale a enfin été proposée en se basant sur les forêts aléatoires pour extraire parmi un ensemble de paramètres physiques un jeu de paramètres permettant de différencier les zones saines des zones pathogènes aux différentes longueurs d’ondes de travail. Une comparaison est proposée avec la littérature et permet de valider l’approche. / Cancer is a pathology that must be detected as soon as possible in order to increase the chances of recovery. These studies investigate the contribution of polarimetric signature to the characterization and identification of cancerous tissues. It is a matter of extracting multidimensional polarization images of the physical information which characterize the constituents of the object well beyond the visual information of the intensity images. During this thesis, a Mueller imager, POLARIS, was set up, as well as the appropriate processing and calibration tools. A method of Mueller images segmentation in non-homogeneous illumination has been proposed. A first database of polarimetric multi-spectral images of healthy and pathogenic tissues in mice was constructed. An original approach was finally proposed based on random forests to extract from a set of physical parameters a set of parameters allowing to differentiate the healthy zones from the pathogenic zones at different working wavelengths. A comparison is proposed with the literature and validates the approach.

Design optimization of truss structures is a popular topic in aerospace, mechanical, civil, and structural engineering due to benefits to industry. Common design problem for the structures is the weight minimization. Especially in aerospace engineering the minimization of the weight of the total structure gets the highest importance in the design. This study focuses on the design optimization of 2D and 3D truss structures. The objective function is the total mass of the structure which is subjected to stress and nodal displacement constraints. To optimize the design, Genetic Algorithm (GA) is preferred due to its efficiency in dealing with problems with discrete design variables as in the case of truss structures. This technique yields more realistic results than linear programming methods. In the thesis, a finite element code is developed for the analysis of planar and space truss structures. The developed finite element solver is coupled with a genetic algorithm optimization code which is also developed as a part of the thesis study. Different truss optimization case studies are performed to demonstrate the performance of the finite element solver and the genetic algorithm optimization code that are developed. It is shown that with the use of adaptive penalty function employing scaled fitnesses, the arbitrariness issue of the factor multiplying the error term in the augmented fitness function can be resolved. It is also shown that significant weight reduction can v be achieved by employing shape optimization together with size optimization compared to pure size optimization.

Harmony search method based optimum design algorithm is presented for the grillage systems. This numerical optimization technique imitates the musical performance process that takes place when a musician searches for a better state of harmony. For instance, jazz improvisation seeks to find musically pleasing harmony similar to the optimum design process which seeks to find the optimum solution. The design algorithm considers the displacement and strength constraints which are implemented from LRFD-AISC (Load and Resistance Factor Design-American Institute of Steel Construction). It selects the appropriate W (Wide Flange)-sections for the transverse and longitudinal beams of the grillage system among 272 discrete W-section designations given in LRFD-AISC so that the design limitations described in LRFD are satisfied and the weight of the system is confined to be minimal. Number of design examples is considered to demonstrate the efficiency of the algorithm presented.

This thesis presents optimization techniques for efficient rendering of complex scenes on mobile devices. The introductory part of the text describes Unity game engine and the topic of mobile game development using this tool. Then follows a presentation of important optimization principles and methods for terrain rendering, large scale rendering of animated objects, rendering of animated water surfaces and of other elements in the scenes. The described methods include both general principles of optimization and specific optimization approaches based on the features of Unity game engine. The implementation of presented methods is described and used in practice in the context of mobile strategy game development.