In order to fully understand the functionality of conformal devices, it is critical to develop computational models built from engineered models of 3-dimensional objects. This thesis established a scanning procedure to engineering 3D digital model for whole organs, known as template engineering. The resultant scanning data enabled designing, manufacturing, and modeling of novel organ healthcare devices. Specifically, we applied template engineering and structured-light scanning techniques to capture the 3D topographical information for whole organ systems. Sequentially, we developed multiphysics models for understanding the device functionality, including the function of devices for microfluidic interface and whole organ mechanical stabilization. / Master of Science / This study facilitated the development of computational models for whole organ healthcare devices. In order to develop a fundamental understanding of conforming biomedical devices for kidney assessment computational models were developed that simulate the interaction between the device and the soft organ. In this work, we generated a digital reconstruction of a porcine kidney model by surface scanning techniques that served as the domain two types of organ-devices interaction simulations: 1) organ-fluid contact problems and 2) organ-solid contact problems. This study proved that multiphysics modeling offers the potential toward the design and modeling of next-generation biomedical devices for whole organ healthcare.