561 |
Synthetic studies on the carpaine alkaloidsMayne, P. M. January 1987 (has links)
This thesis describes synthetic work directed towards the synthesis of the piperidine alkaloids carpamic (1) and pseudocarpamic (100) acids. The introductory chapter reviews the occurrence, structural determination, pharmacological properties and biosynthesis of 2,3,6-trisubstituted piperidines and discusses previous synthetic work. In Chapter Two a synthetic strategy <i>via</i> the 2-azabicyclo [2.2.2]octan-5-ones (156) and (157) is proposed and the use of the imino-Diels-Alder reaction to produce these compounds is described. Chapter Three details the reactions used to convert the ester functionality in (156) and (157) into the methyl group present at C-2 in (100) and (1). In the first section transformations of the bicyclic systems are described. The second section describes the intramolecular Michael reaction of enones (183) and (184), formed as by-products in the imino-Diels-Alder reaction described in Chapter Two, to the ethylene acetals (200) and (204). In the third section unsuccessful attempts to open the bicyclic systems by double Baeyer-Villiger oxidation of dimethyl (217) and diethyl (223) acetals are described. The fourth section contains an NBS-induced rearrangement of benzylidene acetal (160) to benzoate (228) and further transformations of (228) to give (241), which has the required C-2 methyl substituent. Chapter Four describes Baeyer-Villiger oxidations of 2-azabicyclo[2.2.2]octan-5-ones and discusses the factors which may influence the relative proportions of bridgehead and methylene-migrated lactones. In Chapter Five the carpamic and pseudocarpamic acid C-6 side-chains are introduced <i>via</i> Wittig reactions on aldehydes (293) and (284) and methyl N-tosylcarpamate (295) and methyl N-tosylpseudocarpamate (291) are prepared.
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562 |
Polyketide biosynthesisAbell, C. January 1982 (has links)
No description available.
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563 |
Mixed-metal organometallic clustersJackson, Patricia A. January 1988 (has links)
No description available.
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564 |
Studies on benzenoid natural productsJames, K. January 1980 (has links)
No description available.
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565 |
The regio- and stereocontrolled synthesis of allylsilanesThomas, A. P. January 1986 (has links)
No description available.
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566 |
The chemistry of ligand-bridged homodinuclear and heterodinuclear complexesHorton, A. D. January 1985 (has links)
No description available.
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567 |
Synthetic studies on aplysistatin and mucohalic derivativesDemnitz, F. W. J. January 1983 (has links)
No description available.
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568 |
Synthesis of spirocyclic compounds via organoiron complexesPerrior, T. January 1983 (has links)
No description available.
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569 |
Synthesis and chemistry of hexaosmium carbonyl 'raft' clustersJeffrey, J. G. January 1985 (has links)
No description available.
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570 |
The synthesis of cis- and trans-maneonenesKendrick, D. A. January 1984 (has links)
No description available.
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