Because of vague objectives, limited resources, environmental changes, decisions made out of standard procedures, inborn disposition of self interests, as well as differences in personal characteristics, values, and perceptions of its members, an organization becomes the battlefield in pursuit of individual interests. All members within the organization want to wield more power and influences through exploitation of the available resources, thereby resulting in political behaviors within the organization. However, through effective management, some of these political behaviors may enhance value for the organization. Therefore, the organization members perceive political behaviors within the organization, their behaviors, reactions, and attitudes will likely exert influences over the organization. ¡§Knowledge is power¡¨; oftentimes the members within an organization deem their knowledge as the source to cement their own position/status and power. In addition, to solidify the position within the organization, they habitually see knowledge as their own assets and are not willing to share with others. However, in the era of knowledge-based economy, competitive edges of an organization are often the results of knowledge sharing and application. Thus, creating a knowledge-sharing environment has therefore become a crucial topic of discussion. To compete in today¡¦s competitive environments, organizational changes are considered as a must for survival. Success of organizational transformation hinges on vigorous implementation of various transformation measures. Furthermore, it also depends on responses arising from expectation, perception, and level of satisfaction from the organizational members to the on-going organizational changes. Therefore, this research discusses relationships among the three variables: perception of organizational politics, knowledge sharing, and level of satisfaction to organizational changes. Further, it studies interferences of the level of satisfaction on the inter-relationships of the three variables. Since previous studies rarely discuss the inter-relationships of perception of organizational politics, knowledge sharing, and level of satisfaction of organizational changes, this research hopes to probe and explore the inter-relationships of the afore-mentioned variables through empirical studies. Targeted firms for survey in this research are from banks, insurance companies, securities firms, manufacturing companies, shipping and transportation firms, food and beverages services, and telecom companies. A total of 1130 questionnaires have been distributed, of which 1,037 are effective. The empirical findings are summarized as follow: ¡]1¡^The perceptions of organizational politics and organizational change have a significant negative relation . ¡]2¡^The satisfaction of organizational restructuring and knowledge sharing have a significant positive relation . ¡]3¡^The perceptions of organizational politics and knowledge sharing have a significant negative relation . ¡]4¡^The both perceptions of organizational politics and knowledge sharing are interfered by satisfaction of organizational change.