The purpose of this study is empirically investigating four research questions related to manufacturing flexibility. 1) What are the components of manufacturing flexibility? 2) Is there a relationship between manufacturing flexibility and organizational performance? 3) Do integrated strategies strengthen the relationship between manufacturing flexibility and organizational performance? 4) Are there organizational characteristics that strengthen the relationship between manufacturing flexibility and organizational performance? This study used a cross-sectional survey design to collect data from manufacturing organizations in multiple industries. Organizational performance was quantified using common manufacturing measures. Strategic integration and organizational infrastructure were also measured. Data were collected using a self-administered questionnaire. Factor analysis, correlation analysis, and regression were used to analyze the data. The results indicate the variables and expected relationships exist as hypothesized. This study contributes to the manufacturing flexibility body of knowledge by identifying relationships between the manufacturing flexibility component, performance, strategic integration, and organizational infrastructure. The instrument development in this study is of particular value as there are few rigorously developed and validated instruments to measure the manufacturing flexibility components and performance. Understanding these relationships will help practitioners make better decisions in manufacturing organizations as well as enable application of the concepts in this study to other contexts such as service organizations.