Origami has been investigated and demonstrated for engineering applications in recent years. Many techniques for accommodating the thickness of most engineering materials have been developed. In this work, tables comparing performance and manufacturing characteristics are presented. These tables can serve as useful design tools for engineers when selecting an appropriate thickness-accommodation technique for their application. The use of bent sheet metal for panels in thick-origami mechanisms shows promise as a panel design approach that mitigates several trade-offs between performance and manufacturing characteristics. A process is described and demonstrated that can be employed to use sheet metal in designs of origami-adapted mechanisms that utilize specific thickness-accommodation techniques. Data structures based on origami can be useful in the automation of thick-origami mechanism design. The use of such data structures is explained and shown in the context of a program that will automatically create the 3D CAD models and assembly of a thick-origami mechanism using the tapered panels technique based on the input origami crease pattern. Manufacturability in the design of origami-adapted mechanisms is discussed through presenting and examining three examples of origami-adapted mechanisms. As the manufacturability of origami-adapted products is addressed and improved, their robustness will also improve, thereby enabling greater use of origami-adapted design.