The use of Electronic Prescribing Systems (EPS) has significant potential role in improving patient safety and reducing adverse drug events. However, the introduction of these systems can have negative outcome on delivery of care if healthcare providers are not utilizing regularly and accept it. This study aims to explore paediatrician’s attitude towards electronic prescribing systems as well as understand the possible factors affecting user acceptance at tertiary care using the Technology Acceptance Model (TAM). A qualitative research methodology was applied. Semi-structured interviews were developed according to TAM model and used as primary source of collecting empirical data. Seven research participants were interviewed. The findings of this study had identified factors that are important for paediatrician’s acceptance of EPS systems. Although paediatricians are positive to the usefulness of EPS, it appears that there are some acceptance problems due to ease of use concerns and usability issues of the system. The acceptance of EPS can be improved by leveraging ease of use as well as enhancing training.