In the present study, acetyl carnitine, decanoyl carnitine, and palmitoyl carnitine were investigated for their surfactant and solubilizing properties. Decanoyl carnitine and palmitoyl carnitine were found to have surface-active properties while acetyl carnitine was without significant surfactant properties. Surface tension and contact angle were decreased by deanoyl and palmitoyl carnitine. The solubilizing effect of the carnitine analogs on triamcinolone acetonide was investigated. Results suggest that the hydrophobic chain length of carnitine analogs was an important factor affecting their surfactant and solubilizing properties. Palmitoyl and decanoyl carnitine demonstrated a greater solubilizing effect on triamcinolone acetonide than acetyl carnitine.