The D-optimal design problems in polynomial regression models with a one-dimensional control variable and k-dimensional response variable Y=(Y_1,...,Y_k) where there are some common unknown parameters are discussed. The approximate D-optimal designs are shown to be independent of the covariance structure between the k responses when the degrees of the k responses are of the same order. Then, the exact n-point D-optimal designs are also discussed. Krafft and Schaefer (1992) and Imhof (2000) are useful in obtaining our results. We extend the proof of symmetric cases for k>= 2.