Modern day hardware platforms are parallel and diverse, ranging from mobiles to data centers. Mainstream parallel applications execute in the same system competing for resources. This resource contention may lead to a drastic degradation in a program’s performance. In addition, the execution environment composed of workloads and hardware resources, is dynamic and unpredictable. Efficient matching of program parallelism to machine parallelism under uncertainty is hard. The mapping policies that determine the optimal allocation of work to threads should anticipate these variations. This thesis proposes solutions to the mapping of parallel programs in dynamic environments. It employs predictive modelling techniques to determine the best degree of parallelism. Firstly, this thesis proposes a machine learning-based model to determine the optimal thread number for a target program co-executing with varying workloads. For this purpose, this offline trained model uses static code features and dynamic runtime information as input. Next, this thesis proposes a novel solution to monitor the proposed offline model and adjust its decisions in response to the environment changes. It develops a second predictive model for determining how the future environment should be, if the current thread prediction was optimal. Depending on how close this prediction was to the actual environment, the predicted thread numbers are adjusted. Furthermore, considering the multitude of potential execution scenarios where no single policy is best suited in all cases, this work proposes an approach based on the idea of mixture of experts. It considers a number of offline experts or mapping policies, each specialized for a given scenario, and learns online the best expert that is optimal for the current execution. When evaluated on highly dynamic executions, these solutions are proven to surpass default, state-of-art adaptive and analytic approaches.