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Efficient Numerical Methods for Heart Simulation2015 April 1900 (has links)
The heart is one the most important organs in the human body and many other live creatures. The electrical activity in the heart controls the heart function, and many heart diseases are linked to the abnormalities in the electrical activity in the heart. Mathematical equations and computer simulation can be used to model the electrical activity in the heart. The heart models are challenging to solve because of the complexity of the models and the huge size of the problems.
Several cell models have been proposed to model the electrical activity in a single heart cell. These models must be coupled with a heart model to model the electrical activity in the entire heart. The bidomain model is a popular model to simulate the propagation of electricity in myocardial tissue. It is a continuum-based model consisting of non-linear ordinary differential equations (ODEs) describing the electrical activity at the cellular scale and a system of partial differential equations (PDEs) describing propagation of electricity at the tissue scale. Because of this multi-scale, ODE/PDE structure of the model, splitting methods that treat the ODEs and PDEs in separate steps are natural candidates as numerical methods.
First, we need to solve the problem at the cellular scale using ODE solvers. One of the most popular methods to solve the ODEs is known as the Rush-Larsen (RL) method. Its popularity stems from its improved stability over integrators such as the forward Euler (FE) method along with its easy implementation. The RL method partitions the ODEs into two sets: one for the gating variables, which are treated by an exponential integrator, and another for the remaining equations, which are treated by the FE method. The success of the RL method can be understood in terms of its relatively good stability when treating the gating variables. However, this feature would not be expected to be of benefit on cell models for which the stiffness is not captured by the gating equations. We demonstrate that this is indeed the case on a number of stiff cell models. We further propose a new partitioned method based on the combination of a first-order generalization of the RL method with the FE method. This new method leads to simulations of stiff cell models that are often one or two orders of magnitude faster than the original RL method.
After solving the ODEs, we need to use bidomain solvers to solve the bidomain model. Two well-known, first-order time-integration methods for solving the bidomain model are the semi-implicit method and the Godunov operator-splitting method. Both methods decouple the numerical procedure at the cellular scale from that at the tissue scale but in slightly different ways. The methods are analyzed in terms of their accuracy, and their relative performance is compared on one-, two-, and three-dimensional test cases. As suggested by the analysis, the test cases show that the Godunov method is significantly faster than the semi-implicit method for the same level of accuracy, specifically, between 5 and 15 times in the cases presented.
Second-order bidomain solvers can generally be expected to be more effective than first-order bidomain solvers under normal accuracy requirements. However, the simplest and the most commonly applied second-order method for the PDE step, the Crank-Nicolson (CN) method, may generate unphysical oscillations. We investigate the performance of a two-stage, L-stable singly diagonally implicit Runge-Kutta method for solving the PDEs of the bidomain model and present a stability analysis. Numerical experiments show that the enhanced stability property of this method leads to more physically realistic numerical simulations compared to both the CN and Backward Euler (BE) methods.
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Análise numérica de barras gerais 3D sob efeitos mecânicos de explosões e ondas de choque / Numerical analysis of general 3D bars under mechanical effects of explosions and shock wavesPardo Suárez, Sergio Andrés 16 December 2016 (has links)
O presente trabalho consiste no uso do Método dos Elementos Finitos (MEF) para a análise de interação fluido-estruturas de barras com foco em problemas transientes envolvendo explosões ou outras ações com propagação de ondas de choque. Para isso é necessário o estudo de três diferentes aspectos: a dinâmica das estruturas computacional, a dinâmica dos fluidos computacional e o problema do acoplamento. No caso da dinâmica das estruturas computacional deve-se identificar em função da cinemática de deformações, quais são os requisitos para que um elemento seja adequado para analisar tais problemas, tendo em vista que a formulação deve admitir grandes deslocamentos. Para evitar problemas relacionados com aproximações de rotações finitas, opta-se por empregar uma formulação descrita em termos de posições e que leva em consideração os efeitos de empenamento da seção transversal. No caso da dinâmica dos fluidos computacional, busca-se uma formulação para escoamentos compressíveis que seja estável e ao mesmo tempo sensível ao movimento da estrutura, sendo empregado um algoritmo de integração temporal explícito baseado em características com as equações governantes descritas na forma Lagrangeana-Euleriana Arbitrária (ALE). No que se refere ao acoplamento, busca-se modularidade e versatilidade, empregando-se um modelo particionado fraco (explícito) de acoplamento e técnicas de transferência das condições de contorno (Dirichlet-Neummann), sendo estudados os efeitos de utilizar transferência bidirecional ou unidirecional dessas condições de contorno. / This work consists in the use of the Finite Element Method (FEM) for numerical analysis of fluid-bar structures, focusing on transient problems involving explosions or other actions with shock waves propagation. For this purpose, one needs to study three different aspects: the computational structural dynamics, the computational fluid dynamics and the coupling problem. Regarding computational structural dynamics, one need firstly to identify the requirements for an element to be adequate to analyze such problems, taking into account the fact that such element should admit large displacements. In order to avoid problems related to finite rotation approximations and to give a realist representation of a 3D bar structure, we chose a formulation defined in terms of positions and that considers the cross-section warping effects. Regarding computational fluid dynamics, we seek for a stable formulation for compressible flows, and at same time, sensitive to the movement of the structure, leading to an explicit time integration algorithm based on characteristics with governing equations described in the Arbitrary Lagrangian-Eulerian (ALE) form. Regarding to coupling, we chose to use a weak (explicit) partitioning coupling model in order to ensure modularity and versatility. The developed coupling scheme is bases on boundary conditions transfer techniques (Dirichlet-Neummann), and we study the effects of using bidirectional or unidirectional boundary conditions transfers.
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Análise numérica de barras gerais 3D sob efeitos mecânicos de explosões e ondas de choque / Numerical analysis of general 3D bars under mechanical effects of explosions and shock wavesSergio Andrés Pardo Suárez 16 December 2016 (has links)
O presente trabalho consiste no uso do Método dos Elementos Finitos (MEF) para a análise de interação fluido-estruturas de barras com foco em problemas transientes envolvendo explosões ou outras ações com propagação de ondas de choque. Para isso é necessário o estudo de três diferentes aspectos: a dinâmica das estruturas computacional, a dinâmica dos fluidos computacional e o problema do acoplamento. No caso da dinâmica das estruturas computacional deve-se identificar em função da cinemática de deformações, quais são os requisitos para que um elemento seja adequado para analisar tais problemas, tendo em vista que a formulação deve admitir grandes deslocamentos. Para evitar problemas relacionados com aproximações de rotações finitas, opta-se por empregar uma formulação descrita em termos de posições e que leva em consideração os efeitos de empenamento da seção transversal. No caso da dinâmica dos fluidos computacional, busca-se uma formulação para escoamentos compressíveis que seja estável e ao mesmo tempo sensível ao movimento da estrutura, sendo empregado um algoritmo de integração temporal explícito baseado em características com as equações governantes descritas na forma Lagrangeana-Euleriana Arbitrária (ALE). No que se refere ao acoplamento, busca-se modularidade e versatilidade, empregando-se um modelo particionado fraco (explícito) de acoplamento e técnicas de transferência das condições de contorno (Dirichlet-Neummann), sendo estudados os efeitos de utilizar transferência bidirecional ou unidirecional dessas condições de contorno. / This work consists in the use of the Finite Element Method (FEM) for numerical analysis of fluid-bar structures, focusing on transient problems involving explosions or other actions with shock waves propagation. For this purpose, one needs to study three different aspects: the computational structural dynamics, the computational fluid dynamics and the coupling problem. Regarding computational structural dynamics, one need firstly to identify the requirements for an element to be adequate to analyze such problems, taking into account the fact that such element should admit large displacements. In order to avoid problems related to finite rotation approximations and to give a realist representation of a 3D bar structure, we chose a formulation defined in terms of positions and that considers the cross-section warping effects. Regarding computational fluid dynamics, we seek for a stable formulation for compressible flows, and at same time, sensitive to the movement of the structure, leading to an explicit time integration algorithm based on characteristics with governing equations described in the Arbitrary Lagrangian-Eulerian (ALE) form. Regarding to coupling, we chose to use a weak (explicit) partitioning coupling model in order to ensure modularity and versatility. The developed coupling scheme is bases on boundary conditions transfer techniques (Dirichlet-Neummann), and we study the effects of using bidirectional or unidirectional boundary conditions transfers.
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