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The optimal intraocular lens for patients: understanding the factors contributing to post-cataract surgery complicationsMastromonaco, Christina January 2021 (has links)
No description available.
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RET - Finding a new target for uveal melanomaPinto Barreiros Proença, Ana Rita January 2021 (has links)
No description available.
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Expression of cysteinyl leukotriene receptor 1 in uveal melanoma: a novel potential therapeutic targetGarcia de Alba Graue, Paulina January 2021 (has links)
No description available.
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Regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in mouse lung fibroblastsShi, Fangyi January 2021 (has links)
No description available.
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Characterizing colorectal cancer liver metastases «in Vivo» and «in Vitro»Younan, Peter January 2021 (has links)
No description available.
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Myocardial reaction to experimental ischemic injury in the rat.Dusek, Jaroslav January 1971 (has links)
No description available.
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Barriers to tuberculosis drug discovery: the mycobacterial cell wallWhittaker, Caitlin 31 July 2023 (has links) (PDF)
The mycobacterial cell wall is a highly complex macromolecular structure that provides intrinsic resistance to several anti-tuberculosis drugs, making it critical in the success of Mycobacterium tuberculosis infection. Multiple layers encapsulate the cell membrane, including arabinogalactan chains and mycolic acids that are covalently bonded to the peptidoglycan layer, resulting in a highly selectively permeable barrier that is unique to this genus. The current treatment for tuberculosis (TB) utilizes antibiotics that weaken the structural integrity of the cell wall to allow easier access for drugs that have intracellular targets. Although this approach is theoretically effective, patient adherence is often poor owing to the lengthy treatment times and negative side effects associated with the multidrug combination regimen. As such, rational drug design to develop more potent, faster-acting anti-TB compounds requires a comprehensive understanding of the composition and functioning of the mycobacterial cell envelope to ensure effective penetration through this barrier. Bioinformatic approaches to compound validation provide a crucial foundation for drug development, but empirical validation of these molecules can present a serious bottleneck in the drug discovery pipeline. Here, we investigated fluorescent click chemistry as a rapid and inexpensive means of ascertaining molecular properties that impact compound permeation of the mycobacterial cell envelope. The variability in permeation of different click-reactive moieties could be rapidly determined using fluorescent read-outs; this, in combination with the availability of a wide array of click-reactive side chains, presents a potentially powerful platform for establishing the properties required by a compound to effectively cross the mycomembrane. Enzymatic degradation of cell wall components further revealed the resilience of mycobacteria as the resulting organisms, spheroplasts, were capable of surviving in the absence of this seemingly essential protective layer. This presents a potentially novel form of intrinsic resistance whereby stripping of the cell wall could allow for tolerance to cell wall active antibiotics, a previously under-appreciated strategy that has been reported in other pathogenic bacteria. Together, these findings highlight the highly dynamic nature of the mycobacterial cell envelope and the need for further investigation into the properties of this structure that allow for such efficient antibiotic evasion.
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The vascular lesions of renal hypertension in the rabbit.Kipkie, G.F. January 1948 (has links)
No description available.
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The functional role of NCAM1 in pediatric Acute Megakaryoblastic Leukemia (AMKL) associated with the CBFA2T3::GLIS2 gene fusionCheetham, Emma January 2023 (has links)
No description available.
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Frequency of Occurrence of Diagnostic Cytologic Parameters in Basal Cell Carcinoma. A Retrospective Review of 25 CasesYoungberg, George A., Laucirica, R., Leicht, S. S. 01 January 1989 (has links)
Twenty-five cases of cytologic preparations from basal cell carcinomas documented by subsequent tissue material were obtained. The cases were retrospectively analyzed to evaluate the frequency of occurrence of various features that could either be helpful or misleading in the diagnosis. These features included peripheral palisading, Bowenoid nuclei, and keratinized cells. Results from the study include the fact that a major criterion for the histologic diagnosis of basal cell carcinoma (peripheral palisading) could seldom be appreciated in the cytology preparations. Large clusters of cells with crowded nuclei were found in every case and thus represent a useful cytologic parameter. However, because of the frequent absence of peripheral palisading, the study suggests there could be diagnostic confusion with lesions of small cell squamous carcinoma.
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