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Colloidal particle deposition onto charge-heterogeneous substratesRizwan, Tania 11 1900 (has links)
This dissertation investigates the influence of surface heterogeneities on colloid deposition. First, deposition of colloidal particles on a nanofiltration membrane during cross flow membrane filtration was studied under different operating pressures and solution chemistries. An atomic force microscope (AFM) was then used to observe the deposit morphology formed on the membrane. At the initial stages of fouling, more particles preferentially accumulate near the peaks than in the valleys of the rough nanofiltration membrane surface. This study demonstrates that it is difficult to isolate, correlate and assess the effects that physical (roughness) heterogeneity and chemical heterogeneity has on colloid deposition based on experiments involving surfaces where the physical and chemical heterogeneities are uncorrelated or randomly distributed.
In the second phase of the study, the deposition of model colloidal particles onto patterned charge-heterogeneous surfaces was studied both experimentally and theoretically. Controlled charge heterogeneity was created experimentally employing self assembled monolayers of alkanethiols patterned onto gold substrates using a soft lithographic technique. Model colloidal particles and fluorescent nanoparticles were sequentially deposited onto the patterned substrate under no flow (quiescent) conditions, and the deposited structures and the micro-patterns were imaged in situ using a combination of phase contrast and fluorescence microscopy. This study indicates that particles tend to preferentially deposit at the edges of the chemically favourable stripes.
The theoretical investigation involved the formulation of a mathematical model based on Random Sequential Adsorption (RSA). This study showed that a simple binary probability distribution assumed in the model is able to predict the experimental deposit morphology adequately, particularly the periodicity of the underlying patterns on the substrate. Furthermore, the effect of charge heterogeneity on the electrostatic double layer interaction between a particle and a charge heterogeneous planar surface was studied numerically employing a 3D finite element model. In this system, significant lateral forces at close separation distances were observed, and found to be appreciably higher when the particle is near the edge of a heterogeneous region of the substrate. From the above studies, it can be concluded that by altering/controlling the chemical heterogeneity of the substrate, it is possible to achieve significant control on the resulting deposit morphology.
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Colloidal particle deposition onto charge-heterogeneous substratesRizwan, Tania Unknown Date
No description available.
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Hyaluronic acid hydrogel materialsZawko, Scott Andrew 02 February 2011 (has links)
Hyaluronic acid (HA) is one of the primary chemical building blocks of the extracellular matrix and thus is an attractive material for biomedical applications. FDA approved HA-based materials are available as dermal fillers, joint viscosupplements, vitreous substitutes, and abdominal adhesion barriers. The engineering of new HA-based materials and applications is an active area of research. Here we develop several new types of HA-based hydrogels with unique and useful properties. To address the challenge of delivering hydrophobic drugs from hydrophilic hydrogel matrices we have grafted HA hydrogels with [Beta]-cyclodextrin to create hydrogels capable of binding poorly water soluble drugs. To create HA hydrogels with unique anisotropic swelling behavior we have developed a dual-crosslinking technique in which a super-swelling chemically crosslinked hydrogel is patterned with low-swelling photocrosslinked domains. When this dual-crosslinked hydrogel is swelled it contorts into a new shape because of differential swelling among photopatterned regions. To address the challenge of creating hydrogel scaffolds with biomimetic branched porosity we have invented a "crystal templating" technique. This technique grows dendritic crystals throughout a biopolymer solution, crosslinks the biopolymer around the crystals, and washes the crystals away to yield a hydrogel with a dendritic macroporous network. Lastly, we invented a method for patterning a substrate with a microarray of hydrogel compartments. A microarray of living cells is obtained when cells are seeded on the hydrogel patterned substrate. This method addresses the need for an inexpensive, simple method for obtaining living cell microarrays that does not require clean room labs and lithographic expertise. Each of these new materials were based on hyaluronic acid hydrogels but the methods are generalizable to hydrogels of other polymers too. In conclusion, the novel methods in this dissertation are a significant contribution to the engineering of HA-based materials. / text
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