The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is an important economic pest of cotton, Gossypium hirsutum (L.), in the Midsouth region of the United States. Continuous season long infestations may result in four or more insecticide applications per growing season. However, late season applications may only be preventing minor losses when compared to overall yield. Results from this study suggest an opportunity to increase thresholds and potentially eliminate one to two insecticide applications in late bloom. Results from this experiment show no significant differences in yield when all square removal levels were simulated in the fourth and fifth week of bloom. Other factors included irrigation and cotton seed technology. Use of threshold irrigation and ThryvOn cotton resulted in greater yields than non-irrigated cotton and non-ThryvOn cotton. Information from these experiments will be used in future integrated pest management programs for more sustainable cotton production in Mississippi.