L-carnitine is an endogenous compound that has important roles in fatty acid oxidation. Patients with end-stage renal disease (ESRD) who are undergoing haemodialysis may develop a secondary L-carnitine deficiency. Following oral administration of L-carnitine, enterobacteria generate ??-butyrobetaine and trimethylamine with the latter substance extensively N-oxygenated in the liver, to form trimethylamine-N-oxide. Given that patients with ESRD have qualitatively different and higher bacterial populations in the small intestine as compared with healthy subjects, increased formation of trimethylamine and accumulation of trimethylamine-N-oxide would be expected. The clinical significance of these amines is related to their potential to form the carcinogen N-nitrosodimethylamine, contribution to neurological toxicity and "uraemic breath". / The pharmacokinetics of oral L-carnitine display clear non-linearity above a dose of 0.5 g three times a day with an associated increase in plasma concentrations of trimethylamine and trimethylamine-N-oxide. Oral administration of L-carnitine to patients with ESRD undergoing haemodialysis increased plasma concentrations of this substance to levels seen in individuals with normal kidney function and evidence was provided for the accumulation of trimethylamine-N-oxide. / Thesis (PhD)--University of South Australia, 2006.

Dissertation (Ph.D.) -- Worcester Polytechnic Institute. / Keywords: Alometric scaling; Radiopharmaceuticals. Includes bibliographical references (p.158-163).

Diss. (sammanfattning) Göteborg : Univ., 2007. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 6 uppsatser.

Thesis (Ph. D.)--University of Adelaide, Dept of Clinical and Experimental Pharmacology, 1988. / Spine title: Pharmacokinetic investigations of triamterine and its metabolites. Erratum slip inserted. Includes bibliographical references (leaves 227-239).

Thesis (Ph. D.)--Faculty of Pharmacy, University of Sydney, 2004. / Bibliography: leaves 217-253.

Thesis (Ph. D.)--University of Sydney, 2003. / Title from title screen (viewed Apr. 28, 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Faculty of Pharmacy. Includes bibliography. Also available in print form.

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 4 uppsatser.

Thesis (M.Sc. (Pharmacy))--Mahidol University, 1983.

Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009. / Title from title page screen (viewed on July 29, 2009). Research advisor: Bernd Meibohm, Ph.D. Document formatted into pages (xiii, 109 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 95-108).