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Introduction to the Opioid Epidemic: The Economic Burden on the Healthcare System and Impact on Quality of LifeHagemeier, Nicholas E. 01 May 2018 (has links)
Opioid analgesics are commonly used to treat acute and chronic pain; in 2016 alone, more than 60 million patients had at least 1 prescription for opioid analgesics filled or refilled. Despite the ubiquitous use of these agents, the effectiveness of long-term use of opioids for chronic noncancer pain management is questionable, yet links among long-term use, addiction, and overdose deaths are well established. Because of overprescribing and misuse, an opioid epidemic has developed in the United States. The health and economic burdens of opioid abuse on individuals, their families, and society are substantial. Part 1 of this supplement will provide a background on the burden of pain and the impact of opioid abuse on individuals, their families, and society; the attempts to remedy this burden through prescription opioid use; and the eventual downward spiral into the current opioid epidemic, including an overview of opioid analgesics and opioid use disorder and the rise in opioid-related deaths.
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New Antibiotics – Old ProblemsLindquist, Desirae, Burchette, Jessica, Odle, Brian, Cluck, David 01 February 2017 (has links)
No description available.
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HIV Infection: The Future of TherapyCluck, David, Merker, Andrew 01 April 2017 (has links)
No description available.
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Blood Myo-Inositol Concentrations in Preterm and Term InfantsBrion, Luc P., Phelps, Dale L., Ward, Robert M., Nolen, Tracy L., Hallman, N. M. K., Das, Abhik, Zaccaro, Daniel J., Ball, M. B., Watterberg, Kristi L., Frantz, Ivan D., Cotten, C. M., Poindexter, Brenda B., Oh, William, Lugo, Ralph A., Van Meurs, Krisa P., O’Shea, T. M., Zaterka-Baxter, Kristin M., Higgins, Rosemary D. 01 February 2021 (has links)
Objective: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age. Design/Methods: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values. Results: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants). Conclusions: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.
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Secondary Metabolites from <i>Garcinia daedalanthera</i> Pierre Leaves and Their Role in Cancer Chemotherapy and ChemopreventionForestrania, Roshamur Cahyan 24 October 2019 (has links)
No description available.
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Development of New Novel Bacterial Topoisomerase Inhibitors as Promising Antibiotics with a 5-Amino-1,3-dioxane Linker MoietyLi, Linsen 15 November 2019 (has links)
No description available.
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Modular Clickable and Photoactive NAADP Analog for Isolation and Purification of the NAADP ReceptorHe, Shijun 04 September 2019 (has links)
No description available.
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Understanding Antimicrobial ResistanceFloris, Lauren, Cluck, David, Singleton, Abby 01 April 2020 (has links)
Bacteria are remarkably adaptable organisms with an innate ability to circumvent damage if exposed to a toxic environment. Antimicrobial-resistant bacteria are present worldwide, and many common infections are becoming more difficult to treat. Continued resistance is rapidly eliminating treatment options for patients, and the cost burden to treat a multidrug-resistant infection is climbing. Owing to the substantial costs associated with drug development, the introduction of novel antibiotics has lagged behind the increase in bacterial resistance. To address this crisis, pharmacists can take an active role in antimicrobial stewardship and foster understanding of how bacteria evade even the strongest available antimicrobial agents.
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The Characterization of Dried Aluminum Hydroxide Gel Suspensions: Particle Size Analysis and Thermal AnalysisLella, Prathyusha 16 May 2013 (has links)
No description available.
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integraseEidahl, Jocelyn O. 08 August 2013 (has links)
No description available.
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