Thesis (M.S.)--University of Wisconsin--Madison, 1962. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 23-25).

Thesis (Dr. P.H.)--University of Michigan, 1943. / Type-written (carbon copy). Bibliography: leaves [150]-159.

By the 1950s, poliomyelitis (polio) was a major public health and medical issue as it became one of the most communicable diseases for children in the United States and globally. Following the widespread use of vaccinations in the 1950s, and an increased global effort in the late 1980s, cases of polio reduced exponentially in countries that were able to enroll widespread vaccination to their citizens. The elementary pathogenic process includes central nervous system (CNS) involvement which may lead to paralysis in extreme rare circumstances. Through mass-vaccination campaigns and global efforts led by the World Health Organization (WHO), United Nations Children’s Fund (UNICEF), and the Bill & Melinda Gates Foundation, the number of new cases has remained minimal in most of the developed world except in three countries: Pakistan, Afghanistan, and Nigeria. There are multiple reasons why this disease continues to spread in these countries including vaccine-derived disease associated with mutations, geographical logistics, and the presence of anti-vaccine terrorist groups. While this review aims to explore the history, pathogenesis, and epidemiology of polio, a focus will also be placed on why the disease is still prevalent in Pakistan and novel methods that can be taken to ensure that polio is eradicated in the country. The goal should be for poliomyelitis to join the ranks of smallpox and rinderpest, the only two diseases that have ever been completely eradicated through the use of vaccinations and global cooperation.

Comparison of poliovirus strains was carried out to determine the origin of the virus in two isolates obtained during the 1982 outbreak of poliomyelitis in Gazankulu. Comparisons of the outbreak isolates with vaccine and wild-type strains of the same poliovirus type were carried out using four biochemical techniques. SDS-polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional thin-layer chromatography (TLC) and reversed-phase high-performance liquid-chromatography (RP-HPLC) were used for comparing viral capsid proteins. Comparison of poliovirus strains at a genetic level was carried out using two-dimensional oligonucleotide mapping of viral RNA. Results showed the type 1 poliovirus isolate, 5061, to be a novel wild-type poliovirus. The type 2 isolate, 5068, was closely related to the poliovirus type 2 Sabin vaccine strain, P712. It was concluded that the intrinsic variability of poliovirus strains was responsible for the appearance of isolate 5068

Senior honors Thesis--University of Michigan, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 103-106).

Senior honors Thesis--University of Michigan, 1999. / Includes bibliographical references (p. 103-106).

Thesis (M.S.)--Boston University

Thesis (Dr. P.H.)--University of Michigan, 1943. / Type-written (carbon copy). Bibliography: leaves 81-84.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1951. / Typescript. Vita. With this are bound: Effect of dietary restriction on susceptibility of mice to infection with Theiler's GDVII virus / W.L. Davies, S.C. Smith, W.L. Pond, A.F. Rasmussen, Jr., and P.F. Clark. Reprinted from Proceedings of the Society for Experimental Biology and Medicine, vol. 72 (1949), p. [528-531] -- Maternal diet and the influence of thiamine deficiency on Theiler's GD-VII encephalomyelitis in mice / K.H. Maddy, W.L. Davies, W.L. Pond, C.A. Elvehjem, and P.F. Clark. Reprinted from Journal of infectious diseases, vol. 86 (Mar.-Apr. 1950), p. [202]-204. Includes bibliographical references (leaves 56-59).

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