There is extensive evidence that structures in the anterior attentional system (i.e. dorsolateral prefrontal cortex and anterior cingulate) are susceptible to normal aging processes, whereas structural changes in the posterior attentional system are minimal. Using the Stroop priming task, we investigated whether reducing the involvement of the anterior attentional system by pre-cuing the location of the target stimulus would eliminate age differences in interference. Older adults continued to be susceptible to interference when the location cue was ambiguous or invalid, but were less susceptible when the target location of a stimulus was presented with a valid cue.