This thesis was concerned with the branch of Cooperate Social Responsibility known as Cause-Related Marketing, and focused on the moderating effects of cultural orientation and message framing on CRM advertisement effectiveness. The well-established individualist/collectivist cultural domain was employed through application to Taiwanese and Canadian cultural contexts. With regards to framing, differences between altruistically and egoistically framed messages were explored. It was hypothesized that members of collectivist societies would have increased positive attitudes and purchase intentions towards altruistically framed messages, while members of individualistic societies would have more favorable attitudes towards egoistically framed messages. The primary rationale cited was cultural congruency between the participants and the messages. An experimental design was performed, making use of real world style simulated print advertisement copies, as well as pre and post exposure questionnaires. Overall, the two-way interaction between cultural orientation and message framing was upheld, albeit with interesting and notable secondary results. Although the collectivist orientation was correlated with higher altruistic tendencies and as a result higher overall attitudes towards the CRM advertisements presented, this did not translate into higher overall purchase intentions. Potential reasons discussed included the relatively hedonic nature of the product used in the experiment, which could explain the higher overall purchase intentions of the individualistically oriented participants, based on affect-based complementary theory. As well, the increased level of past exposure to and familiarity with CRM campaigns of the individualist group was considered as a possible covariate factor. This was the first study to explicitly relate CRM advertisement attitude to a crosscultural framework through message framing, thereby offering significant theoretical contributions to the social marketing literature. Managerial implications have been stressed throughout, with the findings of clear relevance to the marketer interested in launching CRM campaigns internationally.